What is the treatment regimen for Daflon (diosmin and hesperidin) in chronic venous insufficiency?

Daflon (Diosmin and Hesperidin) Treatment Regimen for Chronic Venous Insufficiency

The standard treatment regimen for Daflon (diosmin and hesperidin) in chronic venous insufficiency is one tablet (500 mg) daily, with results typically seen after 4-8 weeks of continuous use. 1

Dosing Recommendations

Standard Dosing for Chronic Venous Insufficiency

• Initial and maintenance dose: 1 tablet (containing 450 mg diosmin plus 50 mg hesperidin) daily 1
• Duration: Long-term therapy is safe and effective, with studies demonstrating safety even after one year of continuous administration 2
• For venous ulcers, results may take several months to become apparent 1

Alternative Dosing for Hemorrhoidal Disease

For CVI manifested as hemorrhoidal disease, a different dosing schedule is recommended:

• Initial phase: 1 tablet 3 times daily for 4 days
• Followed by: 1 tablet twice daily for 9 days
• Maintenance: 600 mg daily for persistent or recurrent hemorrhoidal flares 1

Mechanism of Action and Benefits

Daflon works through multiple mechanisms:

• Increases venous tone
• Improves lymphatic drainage
• Protects the microcirculation
• Reduces capillary hyperpermeability
• Inhibits inflammatory reactions 3

These actions result in:

• Reduction in leg edema (measured by decreased leg circumference)
• Improvement in venous trophic disorders
• Management of stasis dermatitis and dermatofibrosclerosis
• Acceleration of venous ulcer healing when combined with standard treatment 3

Clinical Efficacy

Daflon has demonstrated significant improvements in:

1. Clinical symptoms:

   • Pain reduction
   • Decreased edema
   • Reduced sensation of heaviness and tightness in the legs 4

2. Quality of life measures:

   • Physical parameters
   • Social functioning
   • Psychological well-being 4, 5

3. CEAP classification: Studies show improvement in CEAP staging after treatment 4

Treatment Duration and Monitoring

• Initial response: Clinical improvement is typically observed within the first 4 weeks of treatment 5
• Full benefits: May take 4-8 weeks to become apparent 1
• For venous ulcers: Several months of treatment may be required 1
• Long-term safety: Demonstrated for continuous administration up to one year 2

Complementary Therapies

While Daflon is effective as a standalone therapy, optimal management of chronic venous insufficiency often includes:

• Compression therapy (30-40 mmHg graduated compression stockings) 6
• Leg elevation
• Regular exercise
• Weight management 6

Common Side Effects

• Gastrointestinal discomfort (primarily gastralgia) 2
• Generally well-tolerated with minimal adverse effects

Clinical Pearls

• Early initiation of treatment is recommended, as many patients delay seeking treatment (average 12.5 years after first symptoms) 4
• Consistent daily dosing is important for maintaining therapeutic effect
• Treatment efficacy has been demonstrated across various stages of chronic venous insufficiency, including advanced stages with skin changes and venous ulcers 3

Daflon's comprehensive mode of action makes it suitable for both early and advanced stages of chronic venous insufficiency, with clinical studies consistently demonstrating 30-60% superiority to placebo or standard of care 1.