Recent Guidelines for Weight Loss Programs
The most effective weight loss program includes a calorie-restricted diet (1200-1500 kcal/day for women and 1500-1800 kcal/day for men), increased physical activity (150-300 minutes/week), and behavioral strategies to facilitate adherence, with a goal of 5-10% weight loss maintained long-term. 1
Dietary Recommendations
Caloric Restriction
- Prescribe a diet with reduced calorie intake using one of these methods:
Diet Types
Various dietary approaches can produce weight loss with similar effectiveness:
- Lower-fat diets (<30% of total calories from fat) 1
- Higher-protein diets (25% of total calories from protein) 1
- Low-carbohydrate diets (<30g/day carbohydrate initially) 1
- Mediterranean-style diet 1
- Low-glycemic-load diet 1
Time-Restricted Eating
- An 8-10 hour eating window with 14+ hours of fasting enhances fat loss and improves cardiovascular endpoints 2
- Early time-restricted eating (e.g., 8:00 AM to 4:00 PM) appears more beneficial for weight and glycemic control 2
Physical Activity Recommendations
- Advise 150-300 minutes/week of moderate-intensity physical activity for initial weight loss 1
- Recommend 200-300 minutes/week of physical activity for weight loss maintenance 1
- Include resistance training 2-3 times/week to preserve lean muscle mass 3
- Exercise alone has modest effects on weight loss but is crucial for long-term weight maintenance 1, 3
Comprehensive Lifestyle Intervention
- Recommend participation in a comprehensive lifestyle program for ≥6 months 1
- Prescribe high-intensity (≥14 sessions in 6 months) interventions provided by trained interventionists 1
- Include regular self-monitoring of food intake, physical activity, and weight 1
- Electronically delivered programs with personalized feedback can be prescribed but may result in smaller weight loss than face-to-face interventions 1
- Some commercial-based programs with evidence of safety and efficacy can be prescribed 1
Weight Loss Pattern and Expectations
- Weight loss is typically maximal at 6 months, with smaller losses maintained for up to 2 years 1
- Expect weight loss of 4-12 kg at 6 months with dietary interventions 1
- After initial weight loss, gradual weight regain of 1-2 kg/year is common 1
- Even modest sustained weight loss of 3-5% produces clinically meaningful health benefits 1
- Greater weight loss (>5%) provides additional benefits for blood pressure, lipids, and glycemic control 1
Special Considerations
Very-Low-Calorie Diets
- Very-low-calorie diets (<800 kcal/day) should only be used in limited circumstances 1
- Require medical supervision due to rapid weight loss and potential health complications 1
- Should be provided by trained practitioners in a medical care setting 1
Weight Loss Maintenance
- Advise participation in a long-term (≥1 year) weight loss maintenance program 1
- Prescribe face-to-face or telephone-delivered maintenance programs with regular contact (monthly or more frequent) 1
- Recommend monitoring body weight regularly (weekly or more frequently) 1
- Consider orlistat as an adjunct to lifestyle modification for eligible adults (BMI ≥27 with comorbidities or BMI ≥30) 4
Managing Weight Loss Plateau
- Verify patient is creating a true 500-750 kcal/day energy deficit 3
- Evaluate dietary composition beyond calories, increasing water-rich foods and limiting high-fat foods 3
- Address psychological factors that may impact weight loss (stress, depression, binge eating) 3
- Consider adjusting physical activity type, intensity, or duration 3
Common Pitfalls and Caveats
- Underestimation of caloric intake and overestimation of physical activity are common barriers 3
- Avoid dietary supplements marketed for weight loss as they lack clear evidence of effectiveness 3
- Weight regain is common and driven by complex biological and behavioral factors 3
- Take a multivitamin once daily at bedtime when using orlistat to prevent nutrient deficiencies 4