What is the treatment for a second-degree burn?

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Last updated: October 15, 2025View editorial policy

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Treatment of Second-Degree Burns

The recommended treatment for second-degree burns includes immediate cooling with clean running water for 5-20 minutes, followed by application of a non-adherent dressing, with silver sulfadiazine cream being indicated for prevention and treatment of wound sepsis. 1, 2

Immediate First Aid Steps

  • Cool the burn immediately with clean running water for 5-20 minutes to limit burn depth progression and reduce pain 1
  • Remove jewelry before swelling occurs to prevent constriction and vascular ischemia 1
  • Consider over-the-counter pain medications (acetaminophen or NSAIDs) for pain management 1
  • Monitor children closely for signs of hypothermia during cooling 1, 3
  • If clean running water is not available, superficial burns with intact skin may be cooled with ice wrapped in cloth (never apply ice directly to the burn) 1, 3

Wound Assessment and Cleaning

  • Clean the wound with tap water, isotonic saline, or an antiseptic solution 1
  • Assess the burn for size, depth, and location to determine appropriate management 1
  • Perform wound care in a clean environment with appropriate pain control 1
  • Burns involving face, hands, feet, genitals, or >10% body surface area (>5% in children) require specialized burn center treatment 1, 3

Dressing Application

  • For small partial-thickness burns managed at home, apply petrolatum, petrolatum-based antibiotic ointment, honey, or aloe vera 1
  • Cover with a clean non-adherent dressing 1
  • For prevention and treatment of wound sepsis, silver sulfadiazine cream 1% can be applied to a thickness of approximately 1/16 inch once to twice daily 2
  • When using silver sulfadiazine, the cream should be reapplied to any areas from which it has been removed by patient activity 2
  • Reapply silver sulfadiazine immediately after hydrotherapy 2
  • When applying dressings on limbs, prevent bandages from creating a tourniquet effect 1
  • Monitor distal perfusion in case of circular dressings 1

Special Considerations for Hand Burns

  • Hand burns require immediate cooling with clean running water to limit tissue damage 3
  • Partial or full-thickness hand burns require evaluation at a specialized burn center due to high risk of functional disability 3
  • For partial-thickness hand burns, loosely cover with a clean, non-adherent dressing and refer to a burn specialist immediately 3

When to Seek Medical Attention

  • Burns involving the face, hands, feet, or genitals require immediate medical attention 1, 3
  • All full-thickness burns require medical attention 1
  • Burns covering >10% body surface area in adults or >5% in children require medical attention 1
  • Signs of inhalation injury (soot around nose/mouth, difficulty breathing, singed nasal hairs) require immediate medical attention 1

Treatment Duration and Follow-up

  • Treatment with silver sulfadiazine cream should be continued until satisfactory healing has occurred or until the burn site is ready for grafting 2
  • Dressings should ideally be re-evaluated daily 1
  • The drug should not be withdrawn while there remains the possibility of infection except if a significant adverse reaction occurs 2

Pitfalls to Avoid

  • Do not use external cooling devices (e.g., Water-Jel dressings) for prolonged periods due to risk of hypothermia 1
  • Do not delay other resuscitation interventions for dressing application in severe burns 1
  • Avoid routine antibiotic prophylaxis for burn patients unless infection is present 1
  • Do not apply butter or oil to burns, as this can lead to further damage 3
  • Do not delay referral for partial or full-thickness burns involving functional areas like hands 3

References

Guideline

Initial Treatment for Second-Degree Burns

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Treatment of Hand Burns

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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