Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 17, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Toothache

  • Single most likely diagnosis
    • Dental caries or tooth decay: This is the most common cause of toothache, resulting from bacterial breakdown of tooth enamel.
  • Other Likely diagnoses
    • Pulpitis: Inflammation of the dental pulp, which can be reversible or irreversible, often caused by deep decay, trauma, or infection.
    • Periodontal disease: Infection of the gums and bone supporting the teeth, which can cause pain if it progresses to the point of affecting the tooth's support structures.
    • Dental abscess: A localized collection of pus in the tissues surrounding the tooth, often resulting from an untreated infection.
    • Cracked tooth syndrome: A condition where a tooth has a crack that can cause pain upon chewing or when exposed to temperature changes.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Trigeminal neuralgia: A chronic pain condition that affects the trigeminal nerve, which can cause intense, shock-like or stabbing pain in parts of the face, including the teeth.
    • Temporomandibular joint (TMJ) disorder: While not typically life-threatening, severe cases can lead to significant morbidity and should be considered, especially if the pain is associated with jaw clicking or locking.
    • Osteomyelitis of the jaw: A bone infection that can be severe and requires prompt treatment to prevent serious complications.
    • Sinusitis: Infection or inflammation of the sinuses can refer pain to the upper teeth and should be considered, especially if accompanied by other symptoms like nasal congestion or facial pressure.
  • Rare diagnoses
    • Eruption cyst: A rare condition where a cyst forms over an erupting tooth, which can cause pain and swelling.
    • Odontogenic keratocyst: A type of cyst that can develop in the jaw and cause tooth displacement or resorption, potentially leading to toothache.
    • Multiple myeloma or other malignancies: Although rare, these conditions can cause toothache among other systemic symptoms and should be considered in the differential diagnosis, especially in patients with a history of cancer or unexplained systemic symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.