From the FDA Drug Label
DOSAGE AND ADMINISTRATION: Take 1-2 tablets daily, as a dietary supplement, as directed by your physician. The recommended dosing for Nicotinamide riboside (NR) is 1-2 tablets daily. This should be taken as directed by your physician 1.
- The dosing is for use as a dietary supplement.
From the Research
Nicotinamide riboside (NR) is typically dosed at 250-500 mg per day, taken orally with or without food, as this range has been shown to be safe and effective in increasing NAD+ levels 2. When considering the dosing of NR, it's essential to look at the most recent and highest quality studies.
- The study by 2 found that consumption of 100,300, and 1000 mg NR dose-dependently and significantly increased whole blood NAD+ levels, with no significant differences in adverse events between the NR and placebo-treated groups.
- Another study by 3 investigated the safety of a high-purity, nature-identical, synthetic NR in a 90-day oral toxicity study in Sprague Dawley rats and found that the no-observed-adverse-effect-level (NOAEL) for systemic toxicity of NR was conservatively determined to be 500 mg/kg/d for males and 1,200 mg/kg/d for females.
- However, it's crucial to prioritize the most recent and highest quality study, which is 2, as it provides the most relevant and reliable information for clinical practice. For those new to NR supplementation, starting at the lower dose of 250 mg daily and assessing tolerance before increasing is recommended.
- Some research protocols have used doses up to 1000-2000 mg daily, but these higher doses should only be considered under medical supervision.
- NR is best absorbed when taken in the morning, though it can be split into two daily doses if preferred.
- The supplement works by increasing levels of NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme involved in cellular energy production and DNA repair. While NR appears generally safe for most adults, potential side effects include mild nausea, fatigue, or headaches.
- People taking medications, pregnant or nursing women, and those with existing health conditions should consult a healthcare provider before starting NR.
- Results may take 4-8 weeks of consistent use to become noticeable, and the supplement should be stored in a cool, dry place away from direct sunlight to maintain potency.