From the Research
There is currently no scientific evidence to suggest that nattokinase reduces potential heart problems associated with cannabis use. Nattokinase is an enzyme derived from fermented soybeans (natto) that has shown some fibrinolytic (clot-dissolving) properties and may have mild effects on blood pressure in some studies, but it has not been specifically studied or proven effective for mitigating cannabis-related cardiovascular risks 1. Cannabis use has been associated with increased heart rate, blood pressure changes, and in some cases, increased risk of cardiovascular events in susceptible individuals.
Key Considerations
- Nattokinase has been studied for its potential cardiovascular benefits, including its effects on blood pressure and atherosclerosis, but these studies do not address its use in the context of cannabis use 2, 1.
- The most recent and highest quality study on nattokinase, a randomized controlled trial published in 2021, found no significant effect of nattokinase supplementation on subclinical atherosclerosis progression or blood pressure in healthy individuals at low risk for cardiovascular disease 1.
- Cannabis use can interact with other medications, including anticoagulants and antiplatelet agents, and may increase the risk of cardiovascular events in susceptible individuals 3.
Recommendations
- If you're concerned about heart health while using cannabis, more established approaches would include:
- Moderation of cannabis use
- Choosing lower-THC products
- Avoiding smoking methods (preferring vaporization or edibles)
- Staying hydrated
- Consulting with a healthcare provider about your specific cardiovascular risk factors
- Anyone with pre-existing heart conditions should speak with their doctor before using cannabis, as no supplement, including nattokinase, should be relied upon to counteract potential cardiovascular effects of cannabis.