What are the key steps and considerations for performing a central line procedure?

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Last updated: October 21, 2025View editorial policy

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Central Line Placement and Management: Key Talking Points

For safe and effective central line placement, follow a standardized protocol that includes proper education, sterile technique, and evidence-based maintenance practices to minimize complications such as infections and thrombosis.

Pre-Procedure Preparation

  • Ensure all healthcare personnel involved in central line procedures undergo comprehensive education and competency assessment before performing these procedures 1
  • Prepare all necessary equipment in advance and create a sterile field 1
  • Perform hand hygiene using either alcohol-based waterless product or soap and water before catheter insertion or manipulation 1
  • Implement maximum sterile barrier precautions including mask, cap, sterile gown, sterile gloves, and large sterile drape covering the patient 1

Site Selection

  • Avoid using the femoral site due to increased risk of infection and thrombosis, especially in ICU settings 1
  • Consider subclavian or internal jugular veins as preferred insertion sites 1
  • For patients requiring hemodialysis, avoid subclavian sites due to risk of stenosis 1
  • Right-sided insertion is generally preferred over left-sided placement to reduce thrombosis risk 2

Insertion Procedure

  • Use ultrasound guidance for catheter insertion to reduce complications and improve success rates 1
  • Apply alcoholic chlorhexidine solution (minimum 2% CHG) to the insertion site and allow it to dry completely before puncturing the skin 1
  • Use either open technique (cephalic vein cut-down) or percutaneous approach, with the open technique offering lower risk of immediate complications 1
  • Verify catheter tip position using intraoperative fluoroscopy, post-operative chest X-ray, or intracavitary ECG method 1
  • Select a catheter with the minimum number of lumens necessary for patient management 1

Post-Procedure Care

  • Monitor vital signs (temperature, pulse, blood pressure, respiratory rate) every 4 hours after the procedure 1
  • Obtain a chest X-ray if the patient experiences dyspnea or chest wall pain 1
  • Place a sterile, transparent dressing over the insertion site and replace it no more than once weekly unless soiled or loose 1
  • Consider daily chlorhexidine bathing for ICU patients over two months of age to reduce infection risk 1

Maintenance and Prevention of Complications

  • Perform routine flushing with saline after completion of any infusion or blood sampling 1
  • For subcutaneous ports not in active use, perform a four-weekly flush; for tunneled cuffed catheters and PICC lines, perform weekly flushes 1, 3
  • Use proper flushing technique with 10mL or larger syringes to prevent catheter damage 3, 2
  • Replace administration sets and needle-less connectors at least every 7 days (or within 24 hours after blood, blood products, or fat emulsion infusions) 1

Infection Prevention and Management

  • Implement a bundle approach to reduce central line-associated bloodstream infections (CLABSI) 1, 4
  • If CLABSI is suspected, collect paired blood cultures from the catheter and a peripheral vein before starting antibiotics 1
  • Use alcohol, iodine tincture, or alcoholic chlorhexidine for skin preparation before blood collection 1
  • Consider empirical antibiotic treatment with vancomycin if CLABSI is suspected before blood culture results are available 1

Troubleshooting Catheter Problems

  • For blocked catheters, check for external causes of resistance such as kinks in the catheter limb or patient position 3
  • Use gentle back-and-forth motion to promote catheter patency, followed by flushing with 10 mL of normal saline using a turbulent flushing technique 3
  • Avoid using syringes smaller than 5 mL as they generate higher pressure that could damage the catheter 3
  • If catheter function cannot be restored, consider radiological assessment to evaluate for mechanical occlusion, catheter malposition, or thrombosis 3

Common Complications and Prevention

  • Infection: Maintain strict aseptic technique and adherence to bundle protocols 5, 6
  • Thrombosis: Consider proper catheter tip positioning at the junction between the superior vena cava and right atrium 1
  • Mechanical complications: Use ultrasound guidance during insertion to minimize risk of pneumothorax, arterial puncture, and malposition 1, 7
  • Air embolism: Ensure all connections are secure and clamp catheters during tubing changes 7

Quality Improvement Measures

  • Implement collaborative performance-improvement initiatives with designated physician and nursing team leaders 1
  • Use checklists to assess compliance with bundle elements 1, 4
  • Empower staff to stop procedures if protocols are not followed 1
  • Monitor CLABSI rates and provide feedback to staff to improve outcomes 4, 6

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Complications and Management of PICC Lines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Troubleshooting a Blocked Chemoport

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Central Line Care and Management: Adopting Evidence-Based Nursing Interventions.

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2021

Research

Central line complications.

International journal of critical illness and injury science, 2015

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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