From the Research
Effectiveness of Niacin for Treating Knee Pain
- Niacin, also known as Vitamin B3, has been studied for its potential in treating knee pain, particularly in the context of osteoarthritis.
- A study published in 2015 1 found that B vitamins, including niacin, accompanied by diclofenac, showed significant pain relief in patients with knee osteoarthritis, with the B vitamin group showing a higher decrease in knee pain and total pain severity compared to the diclofenac and E vitamin groups.
- Another study from 2024 2 investigated the relationship between niacin intake and knee osteoarthritis severity, finding a significant correlation between niacin intake and reduced knee pain and functional degrees after a 48-month follow-up.
- The study suggested that increased niacin intake is linked to reduced knee pain and better function in osteoarthritis patients, with certain subgroups, such as middle-aged individuals and women, benefiting more from increased niacin consumption.
Comparison with Other Treatments
- A study from 2013 3 compared the effect of vitamin D supplementation on knee pain and cartilage volume loss in patients with symptomatic osteoarthritis, finding no significant differences between the treatment and placebo groups.
- This suggests that while niacin may have potential benefits for treating knee pain, other supplements like vitamin D may not be as effective.
Niacin's Mechanism of Action
- Niacin has been shown to have anti-inflammatory, analgesic, and antioxidant effects, which may contribute to its potential benefits in treating knee pain 2.
- However, more research is needed to fully understand the mechanisms by which niacin exerts its effects on knee pain and osteoarthritis.
Important Considerations
- When considering niacin supplementation for knee pain, it is essential to distinguish between prescription niacin products and nonprescription dietary supplement niacin products, as the latter may not be subject to the same regulatory standards 4.