What is the proper procedure for changing a Peripherally Inserted Central Catheter (PICC) dressing?

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Last updated: October 26, 2025View editorial policy

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Proper Procedure for Changing a PICC Dressing

The proper procedure for changing a Peripherally Inserted Central Catheter (PICC) dressing requires using maximal sterile barrier precautions, 2% chlorhexidine in 70% alcohol for skin antisepsis, and either sterile transparent semi-permeable dressings changed weekly or sterile gauze dressings changed every 2 days. 1

Preparation and Hand Hygiene

  • Hand hygiene procedures, including washing hands with conventional soap and water or alcohol-based hand rubs, must be performed before and after all catheter-related interventions 1
  • Use maximal sterile barrier precautions including cap, mask, sterile gown, sterile gloves, and a sterile drape for dressing changes 1
  • Gather all necessary supplies before beginning the procedure to maintain sterility throughout 1

Skin Antisepsis

  • Prepare the skin with a 0.5-2% chlorhexidine preparation with alcohol (2% chlorhexidine gluconate in 70% isopropyl alcohol is preferred) 1
  • If there is a contraindication to chlorhexidine (such as sensitivity or in infants under 2 months), use tincture of iodine, an iodophor, or 70% alcohol as alternatives 1
  • Allow the antiseptic to completely air dry according to manufacturer's recommendations before applying the new dressing 1

Dressing Selection and Application

  • Use either sterile gauze or sterile, transparent, semi-permeable dressing to cover the catheter site 1
  • For the first 1-2 days after insertion, placement of sterile gauze between the PICC entry site and adhesive dressing is appropriate 1
  • If the patient is diaphoretic or if the site is bleeding or oozing, use sterile gauze dressing until this is resolved 1
  • After initial insertion period, use clear, transparent dressings that permit site examination 1

Dressing Change Frequency

  • Replace gauze dressings every 2 days for short-term CVCs 1
  • Replace transparent dressings at least every 7 days 1
  • Change dressings sooner if they become damp, loosened, or visibly soiled 1
  • For tunneled catheters with well-healed exit sites, there is no definitive recommendation regarding the necessity for dressing 1

Catheter Stabilization

  • Use manufactured catheter stabilization devices rather than sutures to secure the catheter whenever feasible 1
  • Sutures should no longer be used routinely for securing the catheter as they may be associated with a higher risk of contamination 1

Additional Considerations

  • Do not apply topical antibiotic ointment or creams on insertion sites as they may promote fungal infections and antimicrobial resistance 1
  • Consider chlorhexidine-impregnated dressings for patients with short-term catheters who are at high risk for infection 1
  • Monitor the catheter site visually when changing the dressing or by palpation through an intact dressing on a regular basis 1

Common Pitfalls and Caveats

  • Never submerge the catheter or catheter site in water; showering may be permitted with appropriate precautions 1
  • Avoid using organic solvents (e.g., acetone, ether) on the skin before or after applying antiseptic 1
  • Never advance a migrated PICC regardless of how far it has been dislodged; guidewire exchange is the appropriate approach if the PICC needs to remain in place 1
  • Daily skin cleansing with a 2% chlorhexidine-impregnated wash cloth may help reduce the risk of catheter-related bloodstream infections 1

By following these evidence-based guidelines for PICC dressing changes, healthcare providers can significantly reduce the risk of complications such as catheter-related bloodstream infections, dislodgement, and site infections, thereby improving patient outcomes.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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