Stanozolol Use as a Performance-Enhancing Drug: Significant Health Risks and Medical Contraindications
The use of stanozolol or any anabolic-androgenic steroid as a performance-enhancing drug is strongly discouraged due to significant health risks including cardiovascular complications, hepatotoxicity, and hormonal disruptions, and should be prohibited by all athletic organizations. 1
Medical Risks of Stanozolol Use
Anabolic-androgenic steroids like stanozolol are associated with life-threatening consequences including sudden cardiac death and myocardial infarction 1
Common side effects include:
- Weight gain, acne, and virilization 1, 2
- Menstrual irregularities and hirsutism in females 1, 2
- Hepatic abnormalities and liver dysfunction 1, 3
- Behavioral and mood alterations 1
- Cardiovascular risks including altered lipid profiles (reduced HDL, elevated triglycerides) 1, 2
- Growth retardation in children and adolescents 1
Even at lower doses used for medical conditions like hereditary angioedema, stanozolol causes significant side effects that require close monitoring 2, 3
Hepatotoxicity Concerns
- Stanozolol is a 17α-alkylated anabolic steroid, which increases its potential for liver toxicity 4
- Research shows stanozolol significantly alters liver enzyme levels and can cause inflammatory or degenerative lesions in centrilobular hepatocytes 4
- The drug can decrease cytochrome P450 and cytochrome b5 levels with chronic use, potentially impairing the liver's ability to metabolize medications and toxins 4
Athletic Organizations' Position
- The American Heart Association and American College of Cardiology explicitly state that performance-enhancing drugs like anabolic-androgenic steroids should be prohibited by schools, universities, and other athletic organizations 1, 5
- Use of these substances may jeopardize athletic eligibility and result in disqualification 1
- Athletes should disclose all medication and supplement use to healthcare providers and governing organizations 1
Medical Recommendations
- Athletes should meet nutritional needs through a healthy, balanced diet without dietary supplements or performance-enhancing drugs 1, 5
- Healthcare providers should directly question athletes about performance-enhancing substance use and counsel them about the known and uncertain medical consequences 1
- The principle of "unreasonable risk" (potential harm without defined benefit) should guide recommendations against substances like stanozolol 5
Medical Use Context
- In medical settings, stanozolol is used at much lower doses (0.5-2 mg daily) for conditions like hereditary angioedema, with careful monitoring for side effects 6, 2, 3
- Even at these lower therapeutic doses, side effects are common and require close supervision with routine clinical, biochemical, and radiologic assessments 2
- The anabolic-to-androgenic ratio of stanozolol is approximately 30:1, which still presents significant androgenic effects despite being marketed as primarily anabolic 6
Conclusion
The medical evidence strongly indicates that stanozolol should not be used as a performance-enhancing drug under any circumstances. There is no "safe" method for using stanozolol for performance enhancement, as even therapeutic doses under medical supervision carry significant risks. Athletes should be educated about these dangers and encouraged to pursue performance goals through proper nutrition, training, and recovery methods that do not jeopardize their health.