What is the dosage of vitamin D3 (Cholecalciferol) in Rise Fast D3 (Vitamin D3 supplement)?

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Last updated: October 27, 2025View editorial policy

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Dosage of Vitamin D3 in Rise Fast D3

Rise Fast D3 contains 50,000 IU of vitamin D3 (cholecalciferol) per dose.

Understanding Vitamin D3 Supplementation

Common Vitamin D3 Dosages

  • Standard daily maintenance doses typically range from 800-2000 IU for most adults 1, 2
  • Higher therapeutic doses of 50,000 IU are commonly used as weekly doses for 8-12 weeks to correct vitamin D deficiency 2
  • Rise Fast D3 contains 50,000 IU per dose, which is considered a high-dose supplement typically used for vitamin D repletion rather than daily maintenance 2

Clinical Context for High-Dose Vitamin D3

  • 50,000 IU doses are typically prescribed as weekly doses for 8 weeks followed by maintenance therapy for patients with vitamin D deficiency 2
  • This high dose (50,000 IU) is equivalent to what might be given monthly for maintenance after initial repletion therapy 1
  • For severe vitamin D deficiency (25(OH)D levels <15 ng/mL), a regimen of 50,000 IU weekly for 8-12 weeks is the standard corrective approach 2

Safety Considerations

Safety Profile of High-Dose Vitamin D3

  • Most international authorities consider vitamin D intake of 2,000 IU daily as absolutely safe 1
  • Doses up to 10,000 IU per day supplemented over several months have not been associated with adverse events in studies 1
  • Hypercalcemia from vitamin D excess in generally healthy adults has only been observed with daily intake >100,000 IU or if 25(OH)D levels exceeded 100 ng/mL 1
  • Long-term supplementation with doses ranging from 5,000 to 50,000 IU/day has been reported as safe in some research settings 3

Important Cautions

  • Single annual high doses (500,000 IU) should be avoided as they may lead to adverse outcomes 1
  • Daily, weekly, or monthly dosing strategies are preferred over less frequent, higher doses 1
  • Monitoring of 25(OH)D levels is recommended when using high-dose supplementation 2

Clinical Applications

Appropriate Use of 50,000 IU Dosing

  • For vitamin D deficiency correction: 50,000 IU weekly for 8-12 weeks 2
  • For maintenance after correction: Either lower daily doses (800-2000 IU) or less frequent high doses (50,000 IU monthly) 1, 2
  • For patients with malabsorption or obesity: Higher or more frequent dosing may be required 2

Monitoring Recommendations

  • Measurement of 25(OH)D levels should be performed after at least 3 months of supplementation 2
  • The goal should be to achieve 25(OH)D levels >30 ng/mL, with some experts recommending 40-50 ng/mL 1
  • An incremental dose of D3 of 40 IU will increase 25(OH)D by approximately 0.4 ng/mL 1

Common Pitfalls

  • Using high-dose supplements (50,000 IU) daily rather than weekly or monthly as intended 1
  • Not ensuring adequate calcium intake alongside vitamin D supplementation 2
  • Failing to transition to appropriate maintenance dosing after the initial repletion phase 2
  • Not monitoring 25(OH)D levels to ensure both efficacy and safety with high-dose supplementation 1

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Vitamin D Supplementation Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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