What are the contraindications of Oseltarmin (Tamiflu)?

From the Guidelines

Tamiflu (oseltamivir) should not be used in patients with known serious hypersensitivity to oseltamivir or any component of the product, as well as in individuals with severe renal impairment, unless adjusted dosing is considered. The medication is contraindicated in individuals who have experienced allergic reactions such as anaphylaxis or serious skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis after previous exposure to the drug 1. Patients with hereditary fructose intolerance should avoid Tamiflu oral suspension due to its sorbitol content. Additionally, caution should be exercised when administering Tamiflu to nursing mothers, as the drug and its active metabolite are excreted in breast milk.

• Contraindications for oseltamivir include:
  • Known serious hypersensitivity to oseltamivir or any component of the product
  • Severe renal impairment (creatinine clearance less than 10 mL/min) without adjusted dosing
  • Hereditary fructose intolerance for oral suspension
• Precautions for oseltamivir include:
  • Use during pregnancy only when the potential benefit justifies the potential risk to the fetus
  • Use in nursing mothers, as the drug and its active metabolite are excreted in breast milk
  • Use in patients with chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease, which increase the risk of bronchospasm when using zanamivir, another antiviral medication for influenza 1. It is essential to consider these contraindications and precautions to minimize the risk of adverse reactions and ensure the safe use of oseltamivir in the treatment and prevention of influenza.

From the FDA Drug Label

Oseltamivir phosphate for oral suspension is contraindicated in patients with known serious hypersensitivity to oseltamivir or any component of the product. Severe allergic reactions have included anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme [see Warnings and Precautions (5.1)] . Patients with known serious hypersensitivity to oseltamivir or any of the components of oseltamivir phosphate for oral suspension

The contraindications of Oseltamivir (Tamiflu) are:

• Known serious hypersensitivity to oseltamivir or any component of the product
• Severe allergic reactions including:
  • Anaphylaxis
  • Serious skin reactions including:
    • Toxic epidermal necrolysis
    • Stevens-Johnson Syndrome
    • Erythema multiforme 2 2

From the Research

Contraindications of Oseltamivir (Tamiflu)

• Oseltamivir is contraindicated in patients who have experienced Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) due to oseltamivir or any other ingredient in the formulation 3.
• Patients with a history of hypersensitivity reactions to oseltamivir should avoid taking the medication 3.
• The use of oseltamivir in patients with a history of SJS/TEN due to other medications should be approached with caution, as the risk of recurrence may be increased 4, 5.

Warnings and Precautions

• Oseltamivir may cause SJS/TEN in rare cases, and patients should be monitored for signs and symptoms of these conditions, such as skin rash, blisters, and mucous membrane lesions 3, 5.
• Patients taking oseltamivir should be advised to seek medical attention immediately if they experience any symptoms of SJS/TEN 3, 5.

Special Populations

• The safety and efficacy of oseltamivir in patients with a history of SJS/TEN have not been established, and these patients should be closely monitored if oseltamivir is prescribed 3, 5.