Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 29, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Bilateral Flank Pain

Single Most Likely Diagnosis

  • Nephrolithiasis (Kidney Stones): This condition is a common cause of bilateral flank pain, especially if the stones are moving or obstructing the ureters. The pain is often severe and can radiate to the groin.

Other Likely Diagnoses

  • Pyelonephritis: An infection of the kidneys that can cause flank pain, fever, and other urinary symptoms. It's more common in women and can be bilateral.
  • Urinary Tract Infection (UTI): While often causing lower urinary tract symptoms, severe or upper UTIs can lead to bilateral flank pain.
  • Musculoskeletal Strain: Overuse or strain of the back muscles can cause flank pain, which might be perceived as bilateral if the strain affects both sides of the back.

Do Not Miss Diagnoses

  • Sepsis from a Urinary Source: A severe infection that can lead to life-threatening sepsis. Early recognition and treatment are crucial.
  • Obstructive Uropathy: Bilateral obstruction of the urinary tract, which can lead to acute kidney injury if not promptly addressed.
  • Retroperitoneal Hemorrhage: Bleeding into the space behind the peritoneum, which can be due to trauma, anticoagulation, or other causes, and requires immediate medical attention.

Rare Diagnoses

  • Polycystic Kidney Disease (PKD): A genetic disorder characterized by the growth of numerous cysts in the kidneys, which can cause chronic flank pain.
  • Vasculitis (e.g., ANCA-associated vasculitis): Inflammation of the blood vessels that can affect the kidneys and cause flank pain among other symptoms.
  • Retroperitoneal Fibrosis: A rare condition where fibrotic tissue forms in the retroperitoneum, potentially encasing and obstructing structures like the ureters.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.