What is the recommended dosage conversion from Xyosted (testosterone enanthate) to testosterone 100mg?

Xyosted (Testosterone Enanthate) to Testosterone 100mg Conversion

When converting from Xyosted (testosterone enanthate) to testosterone 100mg, the recommended equivalent dosage is 100mg of testosterone enanthate weekly, which provides similar therapeutic levels to 100mg of testosterone. 1

Dosage Conversion Guidelines

• Testosterone enanthate (Xyosted) is typically administered at doses of 100-200mg every 2 weeks or 50-100mg weekly to maintain therapeutic testosterone levels 1
• For patients previously on 100mg testosterone, a direct 1:1 conversion to 100mg of testosterone enanthate weekly is appropriate to maintain similar serum testosterone levels 1
• Weekly administration of testosterone enanthate provides more stable hormone levels compared to biweekly dosing, which can help reduce fluctuations in symptoms 1, 2

Administration Considerations

• Xyosted is administered as a subcutaneous injection, typically in the thighs, while traditional testosterone enanthate is often given intramuscularly 1, 3
• Subcutaneous administration offers several advantages over intramuscular injections:
  • Less pain and discomfort at injection site 3
  • Can be self-administered more easily 3
  • Provides more stable testosterone levels with less dramatic peaks and troughs 2

Monitoring Recommendations

• Testosterone levels should be measured 2-3 months after initiating therapy or changing doses 4
• For injectable testosterone formulations, levels should be checked midway between injections, targeting mid-normal values (500-600 ng/dL) 1, 4
• Once stable levels are achieved, monitoring every 6-12 months is typically sufficient 4

Safety Considerations

• There is evidence suggesting injectable testosterone may be associated with greater cardiovascular risk compared to transdermal preparations, possibly due to fluctuating testosterone levels 1, 2
• Weekly administration of testosterone enanthate (as with Xyosted) may help mitigate these risks by providing more stable serum levels compared to less frequent dosing 2
• Monitor for potential side effects including erythrocytosis, which occurs more frequently with injectable testosterone formulations 4

Common Pitfalls and Caveats

• Avoid supraphysiologic testosterone peaks by using appropriate dosing and administration frequency 1, 2
• Be aware that testosterone therapy suppresses spermatogenesis and should not be used in men trying to conceive 4
• Patients who are overweight or obese may require dose adjustments as body weight can affect testosterone pharmacokinetics 4, 5
• Consider cardiovascular risk factors before initiating therapy, as testosterone administration may potentially increase cardiovascular events in high-risk patients 1, 4