Appropriate Dilution of Polymyxin B in Normal Saline
Yes, 750,000 units (7.5 lakh units) of polymyxin B can be safely diluted in 100 ml normal saline for intravenous administration. 1
Polymyxin B Dilution Guidelines
- According to the FDA drug label, polymyxin B for intravenous administration should be dissolved in solutions for parenteral use, with 500,000 units typically diluted in 300 to 500 mL of 5% Dextrose Injection for continuous drip 1
- For a 750,000 unit dose (7.5 lakh units), dilution in 100 ml of normal saline (0.9% Sodium Chloride) is appropriate and within acceptable concentration parameters 1
- Normal saline (0.9% Sodium Chloride) is an acceptable diluent for polymyxin B as explicitly mentioned in the FDA drug label 1
Administration Considerations
- After preparation, solutions for parenteral use should be stored under refrigeration 1
- Any unused portions should be discarded after 72 hours to maintain safety and efficacy 1
- The standard adult dosing of polymyxin B is 15,000 to 25,000 units/kg body weight/day in individuals with normal kidney function 1
- Infusions may be given every 12 hours, but the total daily dose must not exceed 25,000 units/kg/day 1
Important Clinical Considerations
- Renal function must be assessed before administration, as dosage reduction is necessary in patients with kidney impairment 1, 2
- Polymyxin B is primarily eliminated by the kidneys, making dosage adjustment essential in patients with renal insufficiency 2
- Monitor for potential adverse effects including nephrotoxicity and neurotoxicity, which are the most common serious side effects 2, 3
- For patients with multidrug-resistant gram-negative bacterial infections, polymyxin B is often considered a last-resort treatment option 2, 4
Practical Application
- When preparing the solution, ensure complete dissolution of the polymyxin B powder in the normal saline 1
- The diluted solution should be clear and free of particulate matter before administration 1
- For continuous infusion, use an infusion pump to ensure accurate delivery rate 2
- The rate of administration should be controlled to deliver the prescribed dose over the recommended time period 1, 2
By following these guidelines, 750,000 units (7.5 lakh units) of polymyxin B can be safely and effectively administered when diluted in 100 ml of normal saline.