What are the risks of a lumbar puncture (LP)?

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Last updated: March 28, 2025View editorial policy

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From the Guidelines

Lumbar puncture (LP) carries several risks, including post-lumbar puncture headache, bleeding, infection, pain, and nerve damage, with the most common risk being a post-lumbar puncture headache affecting about 10-30% of patients, as reported in the most recent study 1. The risks associated with LP can be minimized by using atraumatic needles, which have been shown to reduce the risk of post-dural-puncture headache by 60% compared to conventional needles 1.

Common Risks

  • Post-lumbar puncture headache: occurs in 10-30% of patients, typically within 48 hours after the procedure, and is caused by cerebrospinal fluid leakage from the puncture site 1
  • Bleeding at the puncture site: rare, but can be reduced by normalizing hemostatic factors such as platelet counts and coagulation parameters 1
  • Infection: rare, but can be minimized with proper sterile technique 1
  • Pain or discomfort during the procedure: common, but can be managed with local anesthesia and sedation 1
  • Nerve damage or irritation: rare, but can cause temporary numbness or tingling in the legs 1

Rare but Serious Risks

  • Brain herniation: very rare, but can occur if there is increased intracranial pressure, which is why doctors typically check for signs of increased pressure before performing the procedure 1
  • Cerebral or spinal hemorrhage: very rare, but can be reduced by normalizing hemostatic factors such as platelet counts and coagulation parameters 1
  • Spinal epidural or subdural cerebral hematoma: very rare, but can be reduced by using atraumatic needles and minimizing the risk of bleeding 1

Minimizing Risks

  • Using atraumatic needles: reduces the risk of post-dural-puncture headache by 60% compared to conventional needles 1
  • Normalizing hemostatic factors: reduces the risk of bleeding and hemorrhage 1
  • Proper sterile technique: minimizes the risk of infection 1
  • Local anesthesia and sedation: manages pain and discomfort during the procedure 1
  • Monitoring for signs of increased intracranial pressure: minimizes the risk of brain herniation 1

From the Research

Risks of Lumbar Puncture

The risks associated with lumbar puncture (LP) include:

  • Post-dural puncture headache (PDPH) 2, 3, 4, 5
  • Hemorrhage 2
  • Herniation 2, 3, 6
  • Infection 2, 3
  • Cranial neuropathies 3
  • Nerve root irritation 3
  • Low back pain 3
  • Stylet associated problems 3
  • Bleeding complications 3

Incidence of Complications

The incidence of complications can be reduced by using proper technique and indications 6. The use of atraumatic needles, such as the Sprotte needle, can also reduce the incidence of PDPH 3, 5. The incidence of complications was found to be 10.3% in a study of 525 adult lumbar punctures, with the majority being minor and consisting of PDPH 4.

Prevention and Treatment

Preventative measures, such as pointing the face of the bevel in the direction of the patient's side and replacing the stylet and rotating the needle 90 degrees before withdrawing the needle, can reduce the incidence of PDPH 3. Treatment strategies for complications, such as PDPH, can include bed rest, although evidence suggests that no bed rest is necessary when using atraumatic needles 5. Familiarity with potential LP complications and their management can equip clinicians to effectively manage these complications through prompt recognition, timely diagnosis, and implementation of appropriate preventative measures 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Dural Puncture Complications.

Neuroimaging clinics of North America, 2025

Research

Complications of lumbar puncture.

Neurologic clinics, 1998

Research

Evidence-based lumbar puncture: best practice to prevent headache.

Hospital medicine (London, England : 1998), 2002

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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