What are the risks of a lumbar puncture (LP)?

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Last updated: March 28, 2025View editorial policy

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From the Guidelines

Lumbar puncture carries several risks, including post-dural-puncture headache, which affects up to 35% of patients, and can be debilitating, but the use of atraumatic needles can significantly reduce this risk. The most common risks associated with lumbar puncture include:

  • Post-dural-puncture headache, which can occur in up to 35% of patients 1
  • Bleeding at the puncture site
  • Infection, although rare with proper sterile technique
  • Pain or discomfort during the procedure
  • Nerve irritation that may cause temporary numbness or tingling in the legs In very rare cases, more serious complications can occur, such as brain herniation, seizures, or spinal hematoma. The risk of complications increases in patients with bleeding disorders, those on blood thinners, or individuals with anatomical abnormalities of the spine. To minimize these risks, patients should remain lying flat for several hours after the procedure, increase fluid intake to help replace cerebrospinal fluid, and report any severe headaches, fever, stiff neck, or neurological symptoms immediately. The use of atraumatic needles has been shown to reduce the risk of post-dural-puncture headache, with a relative risk of 0.40 (95% confidence interval 0.34 to 0.47) compared to conventional needles 1. Additionally, a study published in 2022 found that the incidence of typical post-LP headache ranges from 0.9% to 9.0%, and that more than 85% of post-LP headaches resolve without treatment 1. The use of atraumatic needles is strongly recommended for all patients undergoing lumbar puncture, as they decrease complications and are no less likely to work than conventional needles.

From the Research

Risks of Lumbar Puncture

The risks associated with lumbar puncture (LP) include:

  • Post-dural puncture headache (PDPH) 2, 3, 4
  • Hemorrhage 2, 5
  • Herniation 2, 3
  • Infection 2, 3
  • Cranial neuropathies 3
  • Nerve root irritation 3
  • Low back pain 3
  • Stylet associated problems 3
  • Bleeding complications 3
  • Subdural hematoma 5
  • Spontaneous frontal epidural hematoma 5

Incidence and Severity of Complications

The incidence of complications can be reduced by proper technique and the use of certain needles, such as the Sprotte atraumatic needle 3. The majority of complications are minor in severity, with PDPH being the most common complication 4.

Patient Outcomes

These complications can lead to suboptimal patient outcomes, including significant morbidity and mortality in some instances 2. It is essential for clinicians to be familiar with these complications to effectively manage them through prompt recognition, timely diagnosis, and implementation of appropriate preventative measures 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Dural Puncture Complications.

Neuroimaging clinics of North America, 2025

Research

Complications of lumbar puncture.

Neurologic clinics, 1998

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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