How to Make a Bicarbonate Mouthwash
Mix 1 teaspoon of table salt and three-quarter teaspoon of bicarbonate of soda (baking soda) into 500 ml of water to create an effective sodium bicarbonate mouthwash. 1
Standard Preparation Formula
The most widely recommended formulation in clinical guidelines is:
- 1 teaspoon of table salt 1
- Three-quarter teaspoon of bicarbonate of soda (baking soda) 1
- 500 ml of water 1
This creates a Sodium Chloride Mouthwash Compound BP that contains bicarbonate and is used four times daily (10 ml per rinse). 1
Alternative Simplified Formulation
For patients who prefer a bicarbonate-only solution without salt:
This bland rinse using sodium bicarbonate is specifically recommended by NCCN guidelines for mucositis management. 1
Preparation Instructions
- Use freshly prepared solution daily - make a new batch each day for optimal effectiveness 2, 3
- Mix thoroughly until the bicarbonate and salt are completely dissolved in the water 1
- Store at room temperature and discard any unused portion after 24 hours 2
Usage Guidelines
- Rinse with 10 ml of solution four times daily (QDS) 1
- Swish vigorously in the mouth for optimal cleansing of oral receptors and debris removal 1, 3
- Spit out after rinsing - do not swallow 1
- Use after meals and before bedtime for maximum benefit 1
Clinical Context and Benefits
The bicarbonate mouthwash works by:
- Raising salivary pH to create a less acidic oral environment 2, 3
- Cleansing taste bud receptors which can improve taste changes and reduce nausea 3
- Reducing bacterial colonization, particularly Viridans Streptococci and Moraxella species 2
- Providing a bland, non-irritating rinse that is well-tolerated in inflamed or damaged oral mucosa 1
Important Caveats
- Sodium bicarbonate is preferred over saline alone in patients receiving targeted cancer therapies due to concerns about microbial burden 1
- Plain water can be substituted for general oral hygiene in patients not on targeted therapy, as it promotes better adherence 1
- This is a supportive measure - it does not replace proper oral hygiene with soft toothbrush and appropriate dental care 1
- Avoid commercial mouthwashes with alcohol as these can dry and irritate the oral mucosa 1