How to apply EMLA (lidocaine and prilocaine) cream on a hairy scalp?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: November 20, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

How to Apply EMLA Cream on a Hairy Scalp

Apply a thick layer of EMLA cream directly to the hairy scalp without shaving, cover with an occlusive dressing, and leave in place for at least 1 hour for minor procedures or 2 hours for more painful procedures. 1

Application Technique

Preparation

  • Do not shave the scalp - EMLA is designed for application on intact skin and works effectively even with hair present 1, 2
  • Ensure the scalp skin is intact with no open wounds, as application to non-intact skin dramatically increases systemic absorption and toxicity risk 1, 3
  • Clean the area gently if needed, but avoid creating any breaks in the skin 4

Amount and Coverage

  • Apply a thick layer of cream to the target area - the cream should be visibly thick on the surface 1
  • For dosing reference: 1 gram of EMLA equals a strip 1.5 inches (3.8 cm) long and 0.2 inches (5mm) wide 1
  • For minor procedures: use approximately 2.5 grams over 20-25 cm² of scalp 1
  • For more extensive or painful procedures: use 2 grams per 10 cm² of scalp 1

Occlusive Dressing Application

  • Cover the cream with an occlusive dressing (such as Tegaderm or similar adhesive transparent film) to enhance absorption 4, 1
  • The occlusive covering is essential for adequate anesthesia on hair-bearing skin, as it prevents the cream from drying out and maintains contact with the skin surface 2, 5
  • Add an additional light-blocking dressing over the occlusive layer if photosensitivity is a concern 4

Timing

  • Leave EMLA in place for at least 1 hour for routine minor procedures (such as injections or small biopsies) 1
  • For more painful procedures (such as larger biopsies or laser treatments), apply for at least 2 hours 1
  • Effective anesthesia will persist for 1-2 hours after removal of the cream 1, 2

Critical Safety Considerations

Pediatric Patients

  • Exercise extreme caution in children, especially those under 12 months or weighing less than 10 kg 6, 1
  • Maximum dose for infants 0-3 months or <5 kg: only 1 gram over 10 cm² for maximum 1 hour 1
  • Children must be observed by an adult during application to prevent accidental ingestion or eye contact 1
  • If the child becomes dizzy, excessively sleepy, or develops duskiness of face or lips, remove the cream immediately and seek medical attention - these are signs of systemic toxicity 1, 7

Application Area Limits

  • Never apply excessive amounts over large areas, as this can lead to life-threatening CNS toxicity from systemic absorption of lidocaine and prilocaine 7
  • The scalp is highly vascular, which may increase absorption compared to other body sites 3

Contraindications

  • Do not use near eyes 1
  • Avoid in patients with allergy to amide anesthetics 6
  • Do not use in patients with recent sulfonamide antibiotic use or methemoglobinemia 6

Removal and Procedure Timing

  • Remove the occlusive dressing and wipe off excess EMLA cream thoroughly before the procedure 1
  • Clean the area with antiseptic solution after cream removal 4
  • Perform the procedure immediately after removal for optimal anesthetic effect 1, 5

Common Pitfall to Avoid

The most critical error is applying too much cream over too large an area, particularly in children, which can result in systemic toxicity manifesting as CNS symptoms including seizures 7. Always adhere strictly to maximum dose guidelines based on patient age and weight 1.

References

Research

EMLA. A new and effective topical anesthetic.

The Journal of dermatologic surgery and oncology, 1992

Research

A pharmacokinetic study of a topical anesthetic (EMLA® ) in mouse soft tissue laceration.

Dental traumatology : official publication of International Association for Dental Traumatology, 2012

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

EMLA Cream Effectiveness and Applications

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.