Treatment of Piriformis Syndrome
Start with supervised physical therapy focusing on active exercise programs, specifically piriformis stretching and sciatic nerve mobilization, as this is the first-line treatment recommended by major rheumatology societies. 1
First-Line Conservative Management
Physical therapy should emphasize active interventions over passive modalities:
- Supervised exercise programs are conditionally recommended as superior to passive treatments like massage, ultrasound, or heat therapy 1
- Home exercise programs should include specific piriformis stretches (both hip flexion over 90 degrees and under 90 degrees) and sciatic nerve mobilization techniques 1, 2
- Nerve gliding techniques produce less strain than tensioning techniques and should be preferred 2
- Stretching may be augmented with ultrasound or Fluori-Methane spray application before stretching 3
Address underlying biomechanical factors concurrently:
- Correct leg length discrepancies, weak hip abductors, and associated myofascial involvement 3
- Activity modification and correction of positioning that aggravates symptoms (prolonged hip flexion, adduction, internal rotation) 3
NSAIDs may be used for symptomatic pain relief following principles for other musculoskeletal conditions 1
Second-Line Interventional Treatment
If symptoms persist after at least 3 months of conservative therapy, proceed to local injections:
- Glucocorticoid injections into the piriformis muscle are conditionally recommended for persistent pain 1
- Up to three steroid injection trials should be attempted before considering surgery 3
- Botulinum toxin type A injections have Category A2 evidence showing effectiveness for 8-12 weeks 1
- Image-guided injections (ultrasound or other modalities) are recommended to ensure accurate placement 1, 4
Adjunctive Electrical Modalities
TENS and peripheral nerve stimulation can be incorporated:
- Transcutaneous electrical nerve stimulation (TENS) as part of multimodal pain management 1
- Subcutaneous peripheral nerve stimulation for persistent pain not responding to other therapies 1
Surgical Intervention
Surgery should be considered only after failure of at least 3 months of appropriate conservative treatment:
- Piriformis muscle resection with or without sciatic nerve neurolysis achieved satisfactory results in 83% of surgical candidates 5
- Surgical candidates typically had intractable sciatica despite comprehensive conservative management for 4-72 months 5
- Buttock pain improves more than sciatica with conservative treatments, which may guide surgical decision-making 5
- Piriformis tenotomy and sciatic nerve decompression are the primary surgical options 4
Important Clinical Caveats
Avoid high-velocity spinal manipulation in patients with spinal fusion or advanced spinal osteoporosis 1
The diagnosis remains primarily clinical as no investigations have proved definitive, and electrodiagnostic studies are mainly useful to exclude other causes 3, 6
Buttock pain typically responds better to treatment than sciatic symptoms, which should inform patient expectations and treatment planning 5