Is Kratom (Mitragyna speciosa) harmful?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 4, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Kratom is generally considered bad due to its significant risks, including addiction potential, withdrawal symptoms, liver damage, seizures, and even death, which outweigh its potential benefits. The use of kratom has been associated with medical toxicity and death, although causality is difficult to prove due to the involvement of other psychoactive substances in most cases 1. Some of the key concerns with kratom use include:

  • Addiction potential and opioid-like withdrawal symptoms on cessation of use 1
  • Interaction with other medications and substances, particularly central nervous system depressants 2
  • Lack of regulation, leading to variable quality and potency of kratom products and unpredictable dosing 2
  • Reports of adverse effects, including liver damage, seizures, and death 3, 4
  • Limited evidence for its therapeutic benefits, despite some potential uses for pain relief, opioid withdrawal symptoms, and mood enhancement 5

Given the availability of regulated medications with better safety profiles for conditions like pain and opioid use disorder, it is recommended to consult with a healthcare provider to discuss safer, evidence-based alternatives before considering kratom use. The most recent and highest quality study, published in 2024, highlights the need for awareness of kratom exposure as a key contributor to the opioid crisis, with therapeutic benefits earned at the expense of potentially lethal side effects 5. Overall, the risks of kratom use generally outweigh its potential benefits, and caution is advised when considering its use.

References

Research

Kratom: Substance of Abuse or Therapeutic Plant?

The Psychiatric clinics of North America, 2022

Research

Kratom: a dangerous player in the opioid crisis.

Journal of community hospital internal medicine perspectives, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.