Apomorphine Does Not Speed Up Ejaculation—It May Actually Delay It
No, apomorphine does not speed up ejaculation time. In fact, research suggests it may lengthen the post-ejaculatory interval, which is the opposite of what you're asking about. Apomorphine is a dopamine agonist used for erectile dysfunction, not for managing ejaculation timing 1, 2, 3.
Evidence on Apomorphine and Ejaculation Timing
Effects on Sexual Behavior
Animal studies demonstrate that apomorphine (0.4 mg/kg) actually lengthened the first post-ejaculatory interval in male rats, while it did reduce the number of mounts and intromissions needed to reach ejaculation 2.
The drug facilitates erectile function by acting on dopamine receptors in the hypothalamus (particularly the paraventricular nucleus), but this mechanism does not accelerate ejaculation 2, 4.
Clinical Use Is for Erectile Dysfunction Only
Apomorphine sublingual (2-4 mg) is indicated solely for erectile dysfunction, producing erections in approximately 18-20 minutes in responders, with no established role in ejaculatory disorders 1, 4, 5.
The drug works centrally on brain dopamine receptors to trigger the erection cascade, not on ejaculatory pathways 4, 5.
What Actually Works for Premature Ejaculation
If you're looking to delay ejaculation (treat premature ejaculation), the evidence-based approaches are completely different:
First-Line Pharmacologic Treatment
SSRIs like sertraline (50-200 mg daily) are the AUA/SMSNA guideline-recommended first-line treatment for premature ejaculation, with daily dosing superior to on-demand use 6, 7.
Paroxetine (20 mg daily) demonstrates the strongest ejaculation delay among SSRIs 6, 7.
Topical anesthetics (lidocaine/prilocaine cream applied 20-30 minutes before intercourse) are moderately effective alternatives 6.
Important Caveats
Approximately 40% of patients refuse or discontinue SSRI treatment within 12 months due to concerns about taking antidepressants, side effects, or cost 6, 7.
Avoid abrupt SSRI discontinuation as this can precipitate withdrawal syndrome; always taper 6, 7.
Screen for concurrent erectile dysfunction, as some acquired premature ejaculation may be secondary to ED and should be treated according to AUA ED guidelines 6, 7.
Bottom Line
Apomorphine has no role in speeding up ejaculation and may actually prolong the refractory period after ejaculation based on animal data 2. It is exclusively used for erectile dysfunction 1, 3, 4. If you're seeking treatment for delayed ejaculation or premature ejaculation, entirely different therapeutic approaches are indicated per AUA/SMSNA guidelines 6.