From the Research
Pregnenolone has been shown to have a positive effect on cognitive function, mood regulation, and hormonal balance, and its supplementation may be beneficial for individuals with decreased natural production, particularly in aging individuals 1. The effects of pregnenolone on the body are multifaceted, and its role as a precursor to other hormones, including estrogen, progesterone, testosterone, and cortisol, is well-established. As a supplement, pregnenolone may have several benefits, including:
- Improving memory and cognitive function
- Reducing stress and anxiety
- Enhancing mood and overall brain function
- Supporting hormonal balance, particularly in aging individuals whose natural pregnenolone production has declined Pregnenolone works by influencing neurotransmitter systems in the brain, particularly GABA and glutamate, which affect cognitive processes and mood. Additionally, its interaction with the type-1 cannabinoid receptor (CB1R) has been discovered, highlighting its potential as a therapeutic agent in CB1-related disorders 1. Typical dosages of pregnenolone range from 10-100mg daily, with most people starting at lower doses (10-30mg) to assess tolerance. However, it is essential to note that pregnenolone may have side effects, including irritability, anxiety, headaches, and insomnia, particularly at higher doses. Individuals with hormone-sensitive conditions, seizure disorders, or those taking hormone medications should consult with a healthcare provider before using pregnenolone supplements, as it may interact with these conditions or medications. The most recent and highest-quality study on pregnenolone, published in 2022, highlights its role as an endogenous regulator of CB1R activity and function, providing new perspectives on its therapeutic potential 1. This study suggests that pregnenolone may have a strategic opportunity for therapeutic development in CB1-related disorders, making it a promising area of research for future studies.