Trazodone Availability
Trazodone is approved and marketed in several countries worldwide, including the United States, for the treatment of major depressive disorder in adults. 1
Global Availability
- Trazodone is approved and marketed in most countries worldwide for the treatment of Major Depressive Disorder 2
- In the United States, trazodone has been available since its introduction, with a newer prolonged-release formulation (Oleptro™) approved by the FDA 1
- The medication has been used clinically since at least the early 1980s across multiple countries 3, 4
Formulations Available
- Immediate-release formulation: The conventional form of trazodone is widely available 1
- Prolonged-release once-daily formulation (TzCOAD/Oleptro™): Recently approved in the USA, providing improved tolerability over immediate-release formulations 1
Common Dosing
- Therapeutic doses for depression: 300-400 mg/day in elderly patients, with younger patients tolerating up to 600 mg/day 5
- Off-label use for insomnia: Low-dose trazodone (typically 50 mg) is commonly prescribed 6
- For anxiety and sleep: Doses range from 25-100 mg/day when used off-label 6
Clinical Context
- Trazodone is one of the most commonly prescribed medications for sleep disturbances, despite being FDA-approved only for depression 6
- Survey data from 1999-2010 showed trazodone was the second most commonly used medication for insomnia (0.97% of the population), following benzodiazepine receptor agonists 6
- The medication can be safely combined with other agents like hydroxyzine for insomnia and anxiety management 7
To determine availability in your specific location, contact local pharmacies or healthcare providers, as trazodone is widely distributed internationally but specific formulations and brand names may vary by country. 1, 2