Infusion Rate Calculation for TXA
For 1000mg of TXA in 100ml administered over 30 minutes, the infusion rate is 200 ml/hr.
Mathematical Calculation
The calculation is straightforward:
- Volume to infuse: 100 ml
- Time period: 30 minutes (0.5 hours)
- Rate = Volume ÷ Time = 100 ml ÷ 0.5 hours = 200 ml/hr 1
Clinical Context for TXA Administration
While your question asks about a 30-minute infusion, current evidence-based guidelines recommend different timing for TXA administration:
Standard Trauma/Hemorrhage Dosing
- Loading dose: 1g IV over 10 minutes (not 30 minutes), followed by 1g infusion over 8 hours 1, 2, 3
- For 1g in 100ml over 10 minutes: 600 ml/hr 1
- Maintenance infusion: 1g over 8 hours = 12.5 ml/hr (if using 100ml volume) 1, 2
Critical Timing Considerations
- TXA must be administered within 3 hours of injury onset for maximum benefit 1, 2
- Efficacy decreases by 10% for every 15-minute delay in administration 1, 2, 3
- Administration after 3 hours may paradoxically increase bleeding death risk 1, 2, 3
FDA-Approved Administration Rate
- The FDA label specifies infusion rate should not exceed 1 ml/minute to avoid hypotension 4
- This translates to 60 ml/hr maximum rate for safety 4
Common Clinical Pitfall
A 30-minute infusion (200 ml/hr) for the loading dose is slower than evidence-based recommendations. The standard 10-minute loading dose has been validated in major trials including CRASH-2 (>20,000 patients) and is associated with mortality reduction 1, 5. Delaying the loading dose by administering it over 30 minutes instead of 10 minutes could theoretically reduce efficacy, particularly in time-sensitive bleeding scenarios 1, 2, 3.