What is the most suitable first-line medication for treating panic disorder according to National Institute for Health and Care Excellence (NICE) guidelines?

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First-Line Medication for Panic Disorder According to NICE

Paroxetine (option d) is the most suitable first-line choice for treating panic disorder according to NICE guidelines, as SSRIs—particularly paroxetine and sertraline—are recommended as first-line pharmacotherapy for panic disorder. 1, 2

Why SSRIs Are First-Line

  • SSRIs are explicitly recommended as first-line treatment by multiple international guidelines including NICE, with paroxetine specifically approved and studied extensively for panic disorder. 1, 3, 4

  • Paroxetine was the first SSRI approved specifically for panic disorder with or without agoraphobia, demonstrating significant superiority over placebo in reducing panic attack frequency and associated symptoms. 3, 5

  • Clinical efficacy is well-established: In controlled trials, 51% of paroxetine recipients (10-60 mg/day) had no full panic attacks by weeks 7-9 of treatment, compared to 37% with clomipramine and significantly fewer with placebo. 3

  • Long-term efficacy is maintained: Paroxetine's effectiveness continues through 6 months of treatment and reduces relapse risk, with response rates increasing to 85% by weeks 34-36 in extension studies. 3

Why Benzodiazepines Are NOT First-Line

  • Lorazepam (option a) and diazepam (option b) are reserved for acute panic attacks or short-term use only, not as first-line treatment for panic disorder itself. 6, 4

  • Major dependency risk: Benzodiazepines carry significant risk of promoting dependence with corresponding withdrawal syndromes upon discontinuation, which constitutes a major contraindication to first-line use. 4, 7

  • Guidelines explicitly recommend benzodiazepines as second-line agents due to dependence risks and lack of adequate long-term study support. 2

  • Limited role: Benzodiazepines may be combined with SSRIs only in the first weeks of treatment to provide immediate symptom relief while awaiting SSRI onset of action. 7

Why Other Options Are Incorrect

  • Buspirone (option c) is not mentioned in any panic disorder guidelines or evidence and lacks established efficacy for this indication. 3, 4, 5

  • Imipramine (option e), while a tricyclic antidepressant with proven anti-panic efficacy, is less well tolerated than SSRIs and not considered first-line treatment. 7

Critical Implementation Points

  • Start with subtherapeutic "test" doses of SSRIs, as initial adverse effects can paradoxically include increased anxiety or agitation. 2

  • Expect delayed onset: SSRIs have a lag time of potentially 12 weeks before maximal benefit, which is longer than when used for depression alone. 4, 5

  • Gradual dose escalation is necessary due to tolerability concerns in panic disorder patients. 4

  • Common adverse effects include headache, nausea, somnolence, dry mouth, and insomnia (18-25% incidence), though these are generally better tolerated than tricyclic side effects. 3

  • Superior tolerability profile: Paroxetine demonstrates better overall tolerability than clomipramine with lower incidence of anticholinergic effects, lacks benzodiazepine-type dependence potential, and is safer in overdose than tricyclics. 3, 8

References

Guideline

Treatment of Social Phobia with SSRIs

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Escitalopram versus Alprazolam for Anxiety Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

[Pharmacotherapy of panic disorder].

L'Encephale, 1996

Research

Antidepressants in panic disorder.

International clinical psychopharmacology, 1999

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Management of panic disorder.

Expert review of neurotherapeutics, 2005

Research

Current concepts in the treatment of panic disorder.

The Journal of clinical psychiatry, 1999

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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