What are the treatment options for a sebaceous cyst on the scrotum?

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Last updated: April 9, 2025View editorial policy

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From the Guidelines

Sebaceous cysts on the scrotum should be treated with incision, thorough evacuation of the contents, and probing the cavity to break up loculations, as this approach is effective in managing inflamed epidermoid cysts, as suggested by the guidelines for the diagnosis and management of skin and soft-tissue infections 1. When dealing with a sebaceous cyst on the scrotum, it's essential to note that these cysts are often mistakenly referred to as epidermoid cysts, which contain skin flora in the cheesy keratinous material, even when uninflamed 1.

  • Key considerations for treatment include:
    • Incision and drainage of the cyst
    • Probing the cavity to break up loculations
    • Avoiding unnecessary use of systemic antibiotics, unless there are signs of severe infection, such as high fever, extensive surrounding cellulitis, or severely impaired host defenses 1
  • For small, non-painful cysts, no treatment may be necessary beyond keeping the area clean with mild soap and water.
  • If the cyst becomes infected, showing signs of redness, pain, warmth, or discharge, medical attention is necessary to determine the best course of treatment, which may include antibiotics or surgical intervention.
  • It's crucial to avoid attempting to squeeze or pop the cyst yourself, as this can lead to infection and scarring.
  • While waiting for medical attention, warm compresses applied to the area for 10-15 minutes several times daily may help reduce discomfort, as suggested by general principles of wound care and management of skin and soft-tissue infections 1.

From the Research

Sebaceous Cyst on Scrotum

  • A sebaceous cyst is a benign, closed capsule or sac-like structure found under the skin, typically filled with a semi-solid, cheese-like, or oily material [ 2 ].
  • The standard techniques for excising sebaceous cysts include conventional wide excision, minimal excision, and punch biopsy excision [ 2 ].
  • A proposed two-step method for treating sebaceous cysts involves using a laser to create a small hole for content removal, followed by the complete removal of the cyst wall with a minimal excision about 1 month later [ 2 ].
  • This method allows for the complete removal of the cyst with only a small scar, making it a good alternative for eradicating uninfected cysts, especially large cysts or those in areas of thick skin or cosmetic concern, such as the scrotum [ 2 ].

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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