Differential Diagnosis and Management of Chronic Dizziness with Occipital Headache
The most likely diagnosis is vestibular migraine, and first-line treatment should be NSAIDs (ibuprofen, naproxen, or diclofenac) for acute episodes, with consideration for preventive therapy using beta-blockers (propranolol, metoprolol) or topiramate if symptoms occur ≥2 days per month despite optimized acute treatment. 1
Critical Diagnostic Considerations
Primary Differential: Vestibular Migraine vs. Ménière's Disease
Vestibular migraine is the leading diagnosis given the prolonged duration of dizziness (1 month) with occipital headaches (2 months). 1
Key distinguishing features:
- Vestibular migraine: Attacks lasting hours (can range from minutes to >24 hours), hearing loss less likely, patients often have migraine history with photophobia more common than visual aura 1
- Ménière's disease: Attacks lasting 20 minutes to 12 hours with fluctuating hearing loss, tinnitus, and aural fullness occurring immediately before, during, or after vertigo attacks 1
Red Flags Requiring Urgent Investigation
Occipital headache in any patient warrants diagnostic caution, as isolated occipital and cervical pain are not characteristic of typical primary headache disorders. 1
If the patient is over age 50, aggressively investigate secondary causes including:
- Temporal arteritis (check ESR and C-reactive protein) 2
- Subarachnoid hemorrhage (non-contrast head CT within 6 hours) 2
- Posterior circulation stroke 2
- Chiari I malformation (MRI with sagittal T2-weighted sequence of craniocervical junction) 1
Diagnostic Workup
Essential History Elements
Ask specifically about:
- Vertigo characteristics: True spinning sensation vs. vague dizziness (lightheadedness suggests non-vestibular cause) 1
- Attack duration: Seconds (BPPV), minutes to hours (vestibular migraine), 20 minutes-12 hours (Ménière's) 1
- Positional triggers: Head position changes suggest BPPV 1
- Otologic symptoms: Fluctuating hearing loss, tinnitus, aural fullness during attacks suggest Ménière's 1
- Migraine features: Photophobia, phonophobia, nausea, pulsating quality, unilateral location 1
- Occipital pain triggers: Valsalva maneuver worsening suggests Chiari malformation 1
Physical Examination
Perform:
- Dix-Hallpike maneuver: For triggered episodic dizziness to diagnose BPPV 3, 4
- HINTS examination (head-impulse, nystagmus, test of skew): If acute vestibular syndrome present to differentiate vestibular neuritis from stroke 4
- Neurologic examination: Focal deficits, ataxia, dysarthria suggest central cause 1
- Blood pressure measurement: Rule out orthostatic hypotension 3
- Tinel's sign over occipital nerves: Positive suggests occipital neuralgia 5, 6
Imaging Indications
MRI brain without contrast is preferred over CT for evaluating chronic dizziness with occipital headache. 1
Obtain MRI if:
- New onset headache after age 50 2
- Occipital headache worsened by Valsalva (evaluate for Chiari malformation) 1
- Focal neurologic deficits 1
- Progressive symptoms 1
- Atypical features not fitting vestibular migraine or Ménière's 1
Treatment Algorithm
Acute Management
First-line acute therapy: NSAIDs (ibuprofen 400-600mg, naproxen 500-550mg, or diclofenac potassium 50mg) taken early in the attack 1
Second-line acute therapy: Triptans (sumatriptan 50-100mg orally) if NSAIDs fail after three consecutive attacks 1
Adjunct therapy: Prokinetic antiemetics (metoclopramide 10mg or domperidone 10mg) for nausea/vomiting 1
Avoid: Opioids, barbiturates, and oral ergot alkaloids due to poor efficacy and risk of dependency 1
Preventive Therapy Indications
Consider preventive treatment if the patient remains adversely affected ≥2 days per month despite optimized acute therapy. 1, 7
Additional indications:
- Severe attack intensity or prolonged duration 1
- Overuse of acute medications (≥10 days/month for triptans, ≥15 days/month for simple analgesics) 7
- Significant disability affecting quality of life 1
Preventive Medication Selection
First-line preventive options: 1
- Beta-blockers: Propranolol 80-240mg daily, metoprolol 100-200mg daily, or atenolol 50-100mg daily
- Topiramate: Start 25mg daily, titrate slowly to 100-200mg daily in divided doses
- Candesartan: 16mg daily
Second-line options: 1
- Amitriptyline: 25-150mg at bedtime
- Flunarizine: 5-10mg daily (where available)
Third-line options (for chronic migraine ≥15 headache days/month): 7
- CGRP monoclonal antibodies: Erenumab, fremanezumab, or galcanezumab as monthly subcutaneous injections
Assess efficacy after 2-3 months for oral preventives, 3-6 months for CGRP antibodies. 1, 7
Alternative Diagnoses to Consider
Occipital Neuralgia
If pain is paroxysmal, lancinating, and follows occipital nerve distribution with positive Tinel's sign: 5
- Diagnostic/therapeutic: Greater occipital nerve block with local anesthetic ± corticosteroid
- Treatment: Gabapentin, carbamazepine, or tricyclic antidepressants
- Refractory cases: Pulsed radiofrequency or occipital nerve stimulation
Benign Paroxysmal Positional Vertigo (BPPV)
If dizziness is positional, lasting <1 minute (seconds), without hearing loss: 1
- Diagnosis: Positive Dix-Hallpike maneuver
- Treatment: Epley maneuver (canalith repositioning) 3
Vestibular Neuritis
If acute prolonged vertigo (12-36 hours) without hearing loss: 1
- Treatment: Vestibular rehabilitation, short-term vestibular suppressants (meclizine 25mg three times daily for 3-5 days maximum) 8, 3
Common Pitfalls to Avoid
- Do not assume migraine without thorough investigation in patients over 50 with new-onset symptoms 2
- Do not rely on symptom quality alone (vertigo vs. lightheadedness) to guide diagnosis; use timing and triggers instead 4
- Do not abandon preventive therapy prematurely; full benefit may take 2-3 months to manifest 1, 7
- Do not prescribe long-term vestibular suppressants (meclizine, dimenhydrinate) as they impair central compensation and prolong recovery 3
- Do not miss medication overuse headache in patients using acute medications ≥10 days/month (triptans) or ≥15 days/month (simple analgesics) 7