What is the youngest age at which laryngeal (larynx) cancer can occur?

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From the Research

Laryngeal cancer can occur at any age, but the youngest documented cases have been reported in children as young as 6 years old, though such cases are exceptionally uncommon. Typically, laryngeal cancer is most frequently diagnosed in people aged 55-64, with the average age at diagnosis being around 65 years. The evidence from 1 suggests that laryngeal cancer in patients younger than 30 years is uncommon, with a 5-year relative survival rate lowest among those aged 15 to 19 years. Risk factors that might lead to earlier onset include heavy tobacco and alcohol use, exposure to certain chemicals or toxins, family history, and in rare cases, human papillomavirus (HPV) infection. Younger patients with persistent hoarseness, difficulty swallowing, ear pain, or a lump in the neck should seek medical evaluation, as early detection significantly improves treatment outcomes.

Some key points to consider:

  • The study from 1 analyzed data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program and found that malignancies of the glottis were the most common cancers, followed by supraglottic lesions.
  • The evidence from 2 and 3 also suggests that laryngeal cancer is rare in patients younger than 40 years, with no significant differences in demographic variables or lifestyle habits between younger and older patients.
  • The study from 4 found that overall survival and disease-specific survival were worse among the oldest patients, although a significant proportion was cured.
  • The most recent study from 5 provides updated recommendations on radiotherapy for laryngeal cancers, but does not specifically address the youngest age for laryngeal cancer.

While uncommon in youth, healthcare providers should not dismiss the possibility of laryngeal cancer in younger patients with persistent symptoms, especially if risk factors are present. Early detection and treatment are crucial to improve treatment outcomes, and younger patients should seek medical evaluation if they experience persistent symptoms.

References

5
Research

Radiotherapy for laryngeal cancers.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2022

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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