From the Guidelines
Rhodiola should be used with caution due to its potential to decrease CYP2C9 activity by 21% when taken at a dose of 580 mg/d for 14 d, which may lead to significant drug-drug interactions 1. When considering the use of Rhodiola, it is essential to weigh the potential benefits against the risks, particularly in patients taking prescription medications. The evidence suggests that Rhodiola may interact with various drugs, including those metabolized by CYP2C9, which could lead to adverse effects 1. Some key points to consider when using Rhodiola include:
- Potential benefits: reducing stress, fighting fatigue, and improving mental performance
- Typical recommended dosage: 200-600mg daily, standardized to contain 3% rosavins and 1% salidroside
- Potential side effects: dizziness, dry mouth, or headache
- Drug interactions: may decrease CYP2C9 activity, leading to interactions with prescription medications, especially antidepressants, blood pressure medications, or diabetes drugs 1
- Precautions: consult a healthcare provider before use, especially for pregnant or breastfeeding women, or those taking prescription medications. It is crucial to start with a lower dose to assess tolerance before increasing to the full recommended amount and to monitor for potential interactions or side effects.
From the Research
Rhodiola Rosea Overview
- Rhodiola rosea is an adaptogenic herb that has been used in traditional medicine to stimulate the nervous system, treat stress-induced fatigue and depression, and enhance physical performance 2, 3.
- The herb is believed to have a positive effect on mental performance, cognitive functions, and physical working capacity in humans 4, 5.
Stress Management and Rhodiola Rosea
- Rhodiola rosea extract has been shown to be effective in reducing stress symptoms, including fatigue, weakness, and burnout 2, 3.
- The herb is thought to influence the release of stress hormones and boost energy metabolism, making it a potential treatment for stress-related disorders 2.
- Studies have demonstrated that Rhodiola rosea extract can prevent chronic stress and stress-related complications, and can be used as a comprehensive treatment for stress symptoms 2.
Bioactive Compounds and Efficacy
- The bioactive compounds salidroside and rosavin are believed to be responsible for the adaptogenic effects of Rhodiola rosea 6, 4.
- These compounds have been shown to have a stimulating effect on the central nervous system, and can increase mental performance and physical working capacity in humans 4, 5.
- The efficacy of Rhodiola rosea preparations can vary depending on the content of these bioactive compounds, and standardized extracts are necessary to ensure consistent quality and efficacy 6.
Clinical Evidence and Potential Benefits
- Clinical studies have demonstrated the effectiveness of Rhodiola rosea preparations in alleviating various aspects of life-stress symptoms and stress-induced conditions 3.
- The herb has been shown to have a positive effect on cognitive functions, mental performance, and physical performance, and may be beneficial for individuals experiencing stress, fatigue, and burnout 2, 4, 3.
- Additionally, Rhodiola rosea may have remediating effects on cardiovascular and reproductive health by addressing non-specific stress damage and reversing or healing disrupted physiologies and dysfunctions 3.