Are anxiolytic medications SULT1A1 inhibitors?

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From the Research

Anxiolytic Medications and SULT1A1 Inhibition

  • There is no direct evidence in the provided studies to suggest that anxiolytic medications are SULT1A1 inhibitors 1, 2, 3, 4.
  • However, one study found that 17α-ethinylestradiol, a component of oral contraceptives, is a potent inhibitor of human cytosolic sulfotransferase 1A1 (SULT1A1) due to interactions with isoleucine 89 on loop 1 5.
  • The studies primarily focus on the treatment of anxiety disorders using various classes of drugs, including benzodiazepines, serotonergic antidepressants, and other anxiolytics, but do not explore their relationship with SULT1A1 inhibition 1, 2, 3, 4.
  • The mechanisms of action of anxiolytic medications, such as selective serotonin reuptake inhibitors (SSRIs), are discussed in terms of their effects on serotonergic neurotransmission, but not in relation to SULT1A1 inhibition 3, 4.

References

1
Research

[Drug treatment of anxiety disorders].

La Revue du praticien, 2019

3
Research

SSRIs and conditioned fear.

Progress in neuro-psychopharmacology & biological psychiatry, 2011

4
Research

[Biological basis of anxiety disorders and serotonergic anxiolytics].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2004

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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