From the Research
Renal Dosing Adjustments for Taxane
There are no specific studies provided that directly address the renal dosing adjustments for Taxane (Paclitaxel/Docetaxel) in patients with impaired renal function. However, general principles of drug dosage adjustment in patients with renal impairment can be applied:
- The estimated glomerular filtration rate (GFR) can be used to guide dose adjustment in patients with stable kidney function 1, 2, 3.
- Dosage adjustment is based on the remaining kidney function, most often estimated on the basis of the patient's GFR estimated by the Cockroft-Gault formula or other methods 1, 2, 3.
- The frequency of inappropriate dosing was not significantly different from moderate than that of the severe renal impairment 4.
- In patients with end-stage renal disease, dialysis techniques such as hemodialysis and continuous ambulatory peritoneal dialysis may remove drugs from the body, necessitating dosage adjustment 1.
- Close monitoring of drug effect and toxicity is also needed and can be supported by therapeutic drug monitoring 3.
Key Considerations
- The handling of drugs requires special attention in patients with renal disease, as there is a risk of accumulation and drug overdose if dosage is not adjusted to the stage of renal insufficiency 2.
- Standardization of recommendations is necessary to limit disparities in dosage and drug exposure according to the formula used to estimate renal function 2.
- Medication dosing errors can cause adverse drug reactions or ineffective therapy due to declined renal function in patients with renal insufficiency 5.
Commonly Unadjusted Drugs
- The most common unadjusted drugs in patients with chronic kidney disease include meropenem, cefepime, ciprofloxacin, and rosuvastatin 5.
Note: Taxane (Paclitaxel/Docetaxel) is not specifically mentioned in the provided studies. The information provided is general and may not be directly applicable to Taxane.