What is the half-life of torsemide?

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From the FDA Drug Label

In normal subjects the elimination half-life of torsemide is approximately 3. 5 hours. The half-life of torsemide is approximately 3.5 hours in normal subjects 1.

From the Research

Half-Life of Torsemide

  • The half-life of torsemide is reported to be around 3-4 hours 2
  • Another study mentions that the plasma half-life of torsemide is 3-5 hours, which remains unchanged in chronic renal failure 3
  • The pharmacokinetics of torsemide, including its half-life, are not significantly affected by renal function 4

Factors Affecting Half-Life

  • Torsemide undergoes substantial hepatic elimination, which prevents accumulation in patients with renal insufficiency 4
  • The half-life of torsemide is not related to renal function, and is similar to that of healthy subjects 4

Comparison with Other Diuretics

  • Torsemide has a longer elimination half-life than bumetanide or furosemide 2
  • The diuretic potency of torsemide is higher than that of furosemide on a weight-for-weight basis 5, 3

References

3
Research

Torasemide in advanced renal failure.

Cardiovascular drugs and therapy, 1993

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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