From the Research
Mevalonic acid topical applications are primarily beneficial for individuals with aging skin concerns, hyperpigmentation, or those seeking improved skin texture and tone. People with fine lines, wrinkles, uneven skin tone, or dull complexion may consider incorporating mevalonic acid into their skincare routine. This ingredient works by supporting the skin's natural renewal process and promoting collagen production, as shown in a study published in The Journal of investigative dermatology 1.
Key Benefits of Mevalonic Acid
- Supports skin's natural renewal process
- Promotes collagen production
- Helps maintain skin barrier function
- Promotes cell turnover, making it suitable for most skin types including those who cannot tolerate stronger exfoliants
Typically, mevalonic acid products should be applied once daily, preferably in the evening, after cleansing and before moisturizing. A pea-sized amount is usually sufficient for the entire face. Users should start with lower concentrations (around 0.5-1%) and gradually increase as tolerated to minimize potential irritation. Those with sensitive skin should perform a patch test before full application. Mevalonic acid functions by activating cellular pathways involved in skin repair and regeneration, similar to how retinoids work but often with less irritation, as suggested by a study published in Toxicology letters 2.
Important Considerations
- Start with lower concentrations to minimize potential irritation
- Perform a patch test before full application, especially for sensitive skin
- Mevalonic acid may have pleiotropic effects due to its role in the mevalonate pathway, as discussed in a review published in Clinical biochemistry 3
- The mevalonate pathway has been implicated in various diseases, including cancer, autoimmune disorders, and atherosclerosis, highlighting the importance of careful consideration when using mevalonic acid for therapeutic purposes 3.
Overall, mevalonic acid is a promising ingredient for skincare, particularly for those with aging skin concerns or seeking improved skin texture and tone. However, it is essential to use it judiciously and be aware of its potential effects on the mevalonate pathway, as discussed in a study published in Journal of applied genetics 4. Additionally, mevalonolactone, a related compound, has been shown to inhibit Staphylococcus epidermidis adherence and biofilm formation, which could have implications for wound healing and skin health 5.