Management of TG/HDL Ratio of 1.21 (TG 92 mg/dL, HDL 76 mg/dL)
Your lipid profile is excellent and requires no pharmacologic intervention
Your triglyceride-to-HDL ratio of 1.21 with triglycerides at 92 mg/dL and HDL at 76 mg/dL represents optimal lipid parameters that are strongly protective against cardiovascular disease. 1
Why No Treatment Is Needed
Triglyceride Level Assessment
- Your triglycerides at 92 mg/dL are well below the normal threshold of <150 mg/dL 2
- This level is classified as normal and does not meet criteria for any intervention 3, 2
- Pharmacologic therapy for triglycerides is only considered when levels exceed 200 mg/dL after lifestyle optimization, or immediately when ≥500 mg/dL to prevent pancreatitis 3, 2
HDL Cholesterol Assessment
- Your HDL at 76 mg/dL exceeds the protective threshold of >40 mg/dL for men or >50 mg/dL for women 3
- This HDL level is associated with significantly reduced cardiovascular risk 1
- The combination of low triglycerides (<97 mg/dL) and high HDL (>57 mg/dL) confers the lowest risk profile for ischemic heart disease 1
TG/HDL Ratio Interpretation
- A TG/HDL ratio of 1.21 is well below the concerning threshold of ≥2.5 that predicts increased mortality and cardiovascular events 4
- Ratios below 2.5 are not associated with adverse outcomes in high-risk populations 4
Recommended Approach
Maintain Current Status
- Continue standard cardiovascular risk reduction through lifestyle measures: maintain healthy weight, engage in regular physical activity (≥150 minutes/week moderate-intensity exercise), follow a heart-healthy diet with <7% saturated fat, and avoid smoking 2
- Recheck lipid panel every 2 years if values remain in low-risk range 3
No Pharmacologic Intervention Indicated
- Neither fibrates, niacin, nor statins are indicated with your current lipid profile 3
- Statin therapy would only be considered based on your LDL cholesterol level and overall cardiovascular risk assessment, not based on these triglyceride or HDL values 3, 2