Can Invance (generic name unknown) be administered with lidocaine (local anesthetic) intramuscularly (IM)?

Can Invance Be Administered with Lidocaine IM?

There is no evidence or established guidance for administering "Invance" with lidocaine intramuscularly, as "Invance" does not appear to be a recognized medication name in standard medical references. You should verify the correct medication name before proceeding with any administration plan.

Critical Clarification Needed

• The term "Invance" does not correspond to any standard pharmaceutical product in current medical literature or drug databases 1
• Possible considerations include:
  • Invanz (ertapenem): An antibiotic that can be reconstituted with 1% lidocaine for IM injection 1
  • Invega (paliperidone): An antipsychotic not typically given IM with lidocaine 1
  • A misspelling or regional name variation that requires verification

If You Mean Invanz (Ertapenem)

Yes, Invanz can and should be mixed with 1% lidocaine (without epinephrine) for intramuscular administration to reduce injection pain. This is standard practice for this antibiotic.

Mixing Guidelines for Antibiotics with Lidocaine IM

• Many IM antibiotics are reconstituted with 1% lidocaine without epinephrine to minimize injection discomfort 1
• The lidocaine acts as a local anesthetic at the injection site, not systemically 1
• Never use lidocaine with epinephrine for IM antibiotic reconstitution, as vasoconstrictors can impair drug absorption 1

Safety Considerations for IM Lidocaine Use

• Maximum safe dose of lidocaine without epinephrine is 4.5 mg/kg in adults and 1.5-2.0 mg/kg in children 2
• For typical IM reconstitution (using 1-3 mL of 1% lidocaine), systemic toxicity risk is minimal as doses remain well below toxic thresholds 1, 3
• Avoid in patients with documented amide anesthetic allergy (rare, representing only 1% of adverse reactions) 1

Contraindications to Lidocaine Use

• True allergy to amide-type local anesthetics 1, 4
• Severe cardiac conduction disorders (relative contraindication for larger doses) 1, 5
• Severe hepatic impairment (lidocaine clearance is reduced) 3, 6, 7

Action Steps

1. Verify the exact medication name with pharmacy or prescribing provider before proceeding
2. Check the drug's package insert for specific reconstitution instructions regarding lidocaine compatibility
3. If confirmed as Invanz or similar IM antibiotic: Mix with 1% lidocaine without epinephrine per manufacturer instructions 1
4. If a different medication: Do not proceed until proper compatibility is confirmed through official drug references

Common Pitfall to Avoid

Never assume medication names or mixing compatibility without verification—administering the wrong formulation or incompatible mixture can result in treatment failure, tissue damage, or adverse reactions 1.