From the Research
Magnesium (Mg) Threonate for Migraine Prophylaxis
There is limited information available on the specific use of Magnesium (Mg) threonate for migraine prophylaxis. However, the available evidence on magnesium in general can be considered:
- Magnesium deficiency may play a role in the pathogenesis of migraine headaches by promoting cortical spreading depression, alteration of neurotransmitter release, and the hyperaggregation of platelets 1, 2.
- Studies have shown that preventive treatment with oral magnesium and acute headache treatment with intravenous magnesium may be effective, particularly in certain subsets of patients 1, 2.
- The available evidence suggests that up to 50% of patients during an acute migraine attack have lowered levels of ionized magnesium, and infusion of magnesium results in a rapid and sustained relief of an acute migraine in such patients 2.
- Chronic oral magnesium supplementation may also reduce the frequency of migraine headaches 2, 3.
- Magnesium has a potential role in the prophylaxis of migraine headache, but the results in acute therapy are far less convincing 4.
- A meta-analysis of randomized controlled trials found that oral magnesium supplements significantly alleviated the frequency and intensity of migraine 3.
- Magnesium deficiency can cause neurological complications, and deficits in magnesium have a significant role in the pathogenesis of migraine 5.
Key Findings
- Magnesium may have a potential role in the prophylaxis of migraine headache 4, 3.
- Oral magnesium supplementation may reduce the frequency of migraine headaches 2, 3.
- Magnesium deficiency is related to the pathogenesis of migraine 1, 2, 5.