From the Research
Hemochromatosis and Leukopenia
- Hemochromatosis, an iron overload disorder, has been associated with various hematological abnormalities, including leukopenia (low white blood cell count) 1.
- A study published in 2005 found that some individuals with hemochromatosis have low total blood lymphocyte counts, although the reason for this is unknown 1.
- The study revealed significant associations between total blood lymphocyte counts and the presence of certain human leukocyte antigen (HLA) alleles and haplotypes, suggesting a possible genetic link between hemochromatosis and leukopenia 1.
- Another study published in 2017 discussed the effects of iron overload on hematological disorders, including the potential for oxidative stress to affect blood cells, such as neutrophils, and exacerbate anemia and infections 2.
- However, this study did not specifically address the relationship between hemochromatosis and leukopenia.
- More recent studies have focused on the clinical and genetic findings of iron overload disorders, including hemochromatosis, but have not directly investigated the association with leukopenia 3, 4, 5.