Normal SGOT Levels in Children on Valproate Therapy
The provided evidence does not contain information about normal SGOT (AST) levels in children, either in the general pediatric population or specifically in those on valproate therapy.
What the Evidence Actually Addresses
The studies and guidelines provided focus exclusively on:
- Seizure management protocols and valproate dosing strategies 1, 2, 3
- Therapeutic valproate plasma levels (50-100 μg/mL standard range, with some evidence supporting levels up to 200 μg/mL in refractory cases) 4, 5
- Pharmacokinetics and drug interactions of valproate 6, 7
- Common adverse effects like tremor (20-40% incidence) and gastrointestinal symptoms 8, 6
Critical Gap in Evidence
None of the provided evidence discusses liver enzyme monitoring, SGOT/AST reference ranges, or hepatotoxicity surveillance in pediatric patients on valproate.
Clinical Context from General Medical Knowledge
While not addressed in the provided evidence, normal pediatric AST (SGOT) values typically range from:
- Newborns: 25-75 U/L
- Infants and children: 15-60 U/L
- Adolescents: 10-40 U/L
These values vary by laboratory and methodology used.
Important Caveat
One study mentions valproate-associated hepatotoxicity risk in infants with undiagnosed metabolic conditions 9, but provides no specific guidance on normal enzyme levels or monitoring protocols.
The question cannot be adequately answered using the provided evidence, as it contains no information about SGOT/AST reference ranges in children.