Who prescribes Prolia (denosumab)?

From the Guidelines

Prolia (denosumab) is typically prescribed by several types of healthcare providers, primarily specialists who manage bone health conditions, including endocrinologists, rheumatologists, and gynecologists, as well as primary care physicians who manage osteoporosis and oncologists for patients with cancer-related bone loss. According to the most recent guidelines from the American College of Rheumatology 1, the decision to prescribe Prolia should be based on a thorough evaluation of the patient's fracture risk, bone mineral density, and medical history. Some key points to consider when prescribing Prolia include:

• Evaluating bone mineral density through DEXA scans
• Assessing fracture risk using tools such as FRAX
• Checking calcium and vitamin D levels
• Reviewing the patient's medical history for contraindications such as hypocalcemia or allergies to the medication
• Considering the patient's individual risk factors, such as age, sex, and medical history, when determining the best course of treatment. The American College of Physicians also recommends that clinicians offer pharmacologic treatment with denosumab to reduce the risk for hip and vertebral fractures in women who have known osteoporosis 1. Overall, the prescription of Prolia should be individualized to each patient's specific needs and risk factors, and should be done under the guidance of a qualified healthcare provider.

From the FDA Drug Label

Treatment with Prolia in these patients should be supervised by a healthcare provider with expertise in the diagnosis and management of CKD-MBD [see Dosage and Administration (2.2) and Warnings and Precautions (5.1)]. Prolia should be prescribed by a healthcare provider with expertise in the diagnosis and management of certain conditions, such as CKD-MBD. Key points include:

• Healthcare provider: A doctor or other medical professional with the necessary expertise.
• Expertise: Specifically in the diagnosis and management of CKD-MBD. 2

From the Research

Prolia Prescription Information

• Prolia, also known as denosumab, is a medication used to treat osteoporosis and other bone-related diseases.
• According to the studies, denosumab can be prescribed by healthcare professionals, including doctors and specialists in endocrinology and osteology 3, 4, 5.
• The medication is typically administered via subcutaneous injection once every 6 months 4.
• Denosumab is approved for various indications, including the treatment of postmenopausal women with osteoporosis at increased/high risk of fracture or failure/intolerance of other osteoporosis therapies 4, 5.

Healthcare Professionals Involved in Prolia Prescription

• Endocrinologists: specialists who treat hormone-related diseases, including osteoporosis 3, 4.
• Osteologists: specialists who treat bone-related diseases, including osteoporosis 4, 5.
• Primary care physicians: doctors who provide general medical care and may prescribe denosumab for patients with osteoporosis 5.

Important Considerations for Prolia Prescription

• Denosumab should be prescribed by a healthcare professional who has evaluated the patient's individual needs and medical history 4, 5.
• The medication may be prescribed for patients who have failed or are intolerant to other osteoporosis therapies 4, 5.
• Healthcare professionals should carefully consider the potential benefits and risks of denosumab, including the risk of multiple vertebral fractures after discontinuation 4, 5.