From the Research
Regular blood tests, including a complete blood count, liver function tests, and kidney function tests, are recommended for patients taking Lamictal (lamotrigine) at baseline and then annually thereafter. These tests are crucial in monitoring potential side effects of lamotrigine, such as serious blood disorders or liver problems, as reported in a study on the potential hepatotoxicity of lamotrigine 1. Although the study is from 2000, its findings remain relevant, and more recent studies have not provided conclusive evidence to alter this recommendation.
Monitoring Schedule
The monitoring schedule may vary depending on individual patient factors, such as the presence of underlying medical conditions or concomitant medications. Some providers may recommend more frequent monitoring, especially during the first year of treatment. Blood level monitoring of lamotrigine itself is not routinely required but may be useful in certain situations, such as suspected toxicity, pregnancy, or when medication adherence is a concern 2.
Additional Tests
Patients should also have thyroid function tests periodically, as lamotrigine can occasionally affect thyroid hormone levels. The usefulness of complete blood count (CBC) in assessing cardiovascular and metabolic diseases has been highlighted in a recent literature review 2, but its application in monitoring lamotrigine therapy is not directly established. However, given the potential for lamotrigine to cause blood disorders, a CBC can be a valuable tool in monitoring patients on this medication.
Clinical Judgment
It is essential to follow the healthcare provider's specific recommendations for monitoring, as they may customize the frequency based on the individual health status and medication regimen of the patient. The utility of routine complete blood count, liver function tests, and other screening tests in patients with certain conditions has been questioned in some studies 3, but in the context of lamotrigine therapy, these tests remain important for ensuring patient safety and detecting potential issues before they become serious.