What is an appendicolith in the context of appendicitis?

What is an Appendicolith?

An appendicolith is a calcified stone formed by calcium salts and fecal debris that becomes lodged within the appendiceal lumen, and it serves as a critical radiologic marker that significantly increases the risk of appendiceal perforation, treatment failure with antibiotics, and complicated appendicitis. 1

Physical Characteristics and Detection

• Appendicoliths are composed of concentrically layered calcium salts and fecal debris that accumulate within the appendix 2, 3
• They can be classified into three categories based on hardness: soft (class 1), intermediate (class 2), and stone-hard with concentrically layered structure (class 3, representing 19.5% of cases) 2
• CT imaging readily identifies appendicoliths, which are found in nearly 40% of adults with proven appendicitis, compared to only 4% of those without appendicitis 1
• Plain radiographs detect appendicoliths in less than 10% of appendicitis cases, making CT the superior imaging modality 3

Clinical Significance and Perforation Risk

The presence of an appendicolith dramatically increases the risk of appendiceal complications and should fundamentally alter your treatment approach:

• Appendicoliths predict occult perforation with an odds ratio of 2.47-2.67, with sensitivity of 55.4% and specificity of 68.3% 1
• When combined with intraluminal gas, the odds ratio for perforation increases to 5.7 1
• In patients with complicated appendicitis (gangrenous or perforated), 57.7% have visible appendicoliths on CT, compared to only 38.3% in uncomplicated cases 4
• After adjusting for age, sex, and symptom duration, appendicoliths carry an odds ratio of 3.52 for complicated appendicitis 4

Impact on Treatment Decisions

Appendicoliths are an independent predictor of antibiotic treatment failure and should generally preclude non-operative management:

• The World Society of Emergency Surgery strongly recommends against antibiotic-only treatment when appendicoliths are present 1
• Appendicoliths are associated with higher failure rates of conservative antibiotic management in uncomplicated appendicitis 1
• Patients with appendicoliths measuring ≤5 mm diameter AND C-reactive protein ≤5 mg/dL may potentially be considered for non-operative management, though this remains controversial 5
• Appendicoliths >10 mm diameter or CRP >10 mg/dL are absolute indications for surgical intervention due to high perforation risk 5

Surgical Considerations and Complications

When operating on patients with appendicoliths, specific technical precautions are mandatory:

• Extraluminal appendicoliths are pathognomonic for appendiceal perforation 3
• Retained appendicoliths after surgery serve as infected nidi and are the definitive source of postoperative intra-abdominal abscesses 3, 6
• Systematic double ligature of the appendiceal base is essential to prevent appendicolith escape into the peritoneal cavity during laparoscopic appendectomy 6
• If an extraluminal appendicolith is identified on imaging after conservative treatment of periappendiceal abscess, interval appendectomy with intraoperative localization and removal of the stone is indicated 3

Diagnostic Algorithm When Appendicolith is Present

Follow this approach when CT identifies an appendicolith:

• Measure the maximum stone diameter and obtain serum CRP level 5
• Assess for secondary signs: wall thickness >3 mm, focal wall defects, intraluminal gas, periappendiceal fat stranding, or fluid collections 1, 7
• If stone >10 mm OR CRP >10 mg/dL OR any secondary signs of perforation are present, proceed directly to appendectomy 5
• If stone ≤5 mm AND CRP ≤5 mg/dL AND patient strongly refuses surgery, antibiotic therapy may be attempted with close monitoring, but surgical treatment remains preferred 1, 5
• Initiate broad-spectrum IV antibiotics covering gram-negative organisms and anaerobes regardless of treatment pathway 8