What is the difference between Hyperlipidemia (ICD10 E78) and Pure hypertriglyceridemia (ICD10 E78.2)?

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Last updated: April 16, 2025View editorial policy

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From the Guidelines

When coding for billing or medical documentation, it is recommended to use the most specific ICD-10 code available, such as E78.2 for mixed hyperlipidemia, rather than the broader category E78, to ensure greater clinical precision and accurate reimbursement. This approach is crucial for conditions requiring ongoing management with medications like statins, fibrates, or other lipid-lowering therapies, as it allows for better tracking of patient conditions and coordination of care. According to the most recent evidence 1, addressing and treating lifestyle factors, secondary factors, and medications that raise triglycerides is essential in managing hypertriglyceridemia. The use of specific codes like E78.2 for mixed hyperlipidemia, E78.0 for pure hypercholesterolemia, E78.1 for pure hypertriglyceridemia, E78.3 for hyperchylomicronemia, E78.4 for other hyperlipidemia, and E78.5 for hyperlipidemia unspecified, enables healthcare providers to accurately document and manage lipid disorders, which is vital for reducing the risk of cardiovascular disease and improving patient outcomes, as highlighted in studies focusing on lipid management and cardiovascular risk reduction 1. In clinical practice, the choice between E78 and E78.2 should be guided by the specific diagnosis and the need for precise documentation to support patient care and reimbursement, with the most recent guidelines emphasizing the importance of accurate coding for effective disease management 1.

From the FDA Drug Label

The FDA drug label does not answer the question.

From the Research

ICD10 E78 vs E78.2

  • ICD10 E78 refers to disorders of lipid metabolism, which includes a range of conditions such as hypercholesterolemia, hypertriglyceridemia, and mixed hyperlipoproteinemia 2.
  • E78.2 is a specific code for hyperlipidemia, which is a condition characterized by elevated levels of lipids in the blood.

Key Differences

  • The main difference between E78 and E78.2 is that E78 is a broader code that encompasses various disorders of lipid metabolism, while E78.2 is a more specific code for hyperlipidemia.
  • Hyperlipidemia (E78.2) is a condition that can increase the risk of cardiovascular disease, and treatment options may include lifestyle changes, statins, and other medications 3, 4.

Treatment Options

  • Treatment for disorders of lipid metabolism, including hyperlipidemia, may involve lifestyle changes, such as diet and exercise, as well as medications like statins, ezetimibe, and niacin 2, 5, 6.
  • In some cases, more intensive treatments like LDL apheresis may be necessary for patients with very high levels of LDL cholesterol or those who have not responded to other treatments 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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