How Clobetasol Propionate 0.05% Topical Solution is Supplied
Clobetasol propionate 0.05% topical solution is not specifically listed in the FDA labeling provided, which only documents gel, cream, and ointment formulations in 15g, 30g, 45g, and 60g tubes. 1
Available Formulations from FDA Labeling
The FDA-approved clobetasol propionate 0.05% products are supplied as follows: 1
- Gel formulation: 15g, 30g, and 60g tamper-evident tubes 1
- Cream formulation: 15g, 30g, 45g, and 60g tamper-evident tubes 1
- Ointment formulation: 15g, 30g, 45g, and 60g tamper-evident tubes 1
Storage Requirements
- All formulations should be stored at controlled room temperature 15°-30°C (59°-86°F) 1
- Do NOT refrigerate 1
Solution Formulation for Scalp Application
While the FDA label provided does not list a solution formulation, clinical guidelines indicate that solution, foam, or spray formulations are preferred for scalp psoriasis over cream or ointment, as they penetrate hair-bearing areas more effectively. 2
- For scalp conditions like atopic dermatitis or psoriasis, solution formulations allow better penetration through hair 2
- The maximum weekly amount of clobetasol propionate 0.05% solution, foam, or spray should not exceed 50g 2
Clinical Context for Scalp Atopic Dermatitis
- Studies demonstrate 81% of patients achieve 50% or better clearing with twice-daily clobetasol solution after 2 weeks for scalp conditions 2
- Treatment should be limited to 2 weeks maximum for initial therapy, followed by gradual tapering 2
- Folliculitis is the most common side effect with scalp application 2, 3
If you need to prescribe clobetasol solution specifically, you may need to verify with your pharmacy or manufacturer regarding current availability, as the FDA label provided only documents gel, cream, and ointment formulations. 1