From the Research
The use of berberine in non-diabetic people has been studied in peer-reviewed research, with the most recent and highest quality study suggesting its potential benefits in improving metabolic disorders, including hyperlipidemia and obesity, as seen in the 2024 study published in Current Medicinal Chemistry 1.
Key Findings
- Berberine has been shown to have anti-obesity and antidiabetic effects, as well as antibacterial activity against various microbiota 1.
- The mechanism behind berberine's effects involves activation of AMP-activated protein kinase (AMPK), which regulates metabolism in multiple tissues 2.
- Typical dosages of berberine in studies range from 500mg to 1500mg daily, usually divided into 2-3 doses taken with meals.
- Berberine may help reduce cholesterol levels in non-diabetic individuals, with a significant reduction in total cholesterol, triglycerides, and low-density lipoprotein cholesterol, and an increase in high-density lipoprotein cholesterol, as seen in the 2013 meta-analysis published in Planta Medica 3.
Safety and Side Effects
- Berberine is generally considered safe for short-term use (up to 3-6 months), with common side effects including gastrointestinal discomfort, constipation, or diarrhea.
- Berberine may interact with certain medications, particularly those metabolized by CYP enzymes, so consultation with a healthcare provider is recommended before starting supplementation, especially for individuals taking other medications.
Recommendations
- Berberine may be considered as a potential adjunctive treatment for non-diabetic individuals with metabolic disorders, such as hyperlipidemia and obesity, under the guidance of a healthcare provider 1.
- Further research is needed to fully understand the effects of berberine in non-diabetic populations and to establish its long-term safety and efficacy.