From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Yes, berberine has been extensively studied in peer-reviewed research, with the most recent and highest quality study published in 2025, demonstrating its efficacy and safety in combination with cinnamon supplementation in patients with type 2 diabetes. Numerous clinical trials and scientific studies examining berberine's effects on various health conditions have been published in reputable medical and scientific journals, including the European Journal of Nutrition 1. Research has particularly focused on berberine's potential benefits for metabolic conditions like type 2 diabetes, high cholesterol, and obesity.
Key Findings
- Typical dosages used in these peer-reviewed studies range from 900-1500 mg daily, usually divided into 2-3 doses taken with meals.
- The compound works primarily by activating AMP-activated protein kinase (AMPK), an enzyme that regulates metabolism, and by influencing various cellular pathways involved in glucose and lipid metabolism.
- A 2025 study published in the European Journal of Nutrition found that daily supplementation with 1200 mg berberine in combination with 600 mg cinnamon for 12 weeks significantly reduced fasting blood sugar and hemoglobin A1C levels in patients with type 2 diabetes, compared to a placebo group 1.
Considerations
- While berberine shows promise in these peer-reviewed studies, it's essential to note that it may interact with certain medications and can cause digestive side effects like constipation, diarrhea, or stomach upset.
- Anyone considering berberine supplementation should consult with a healthcare provider before starting, especially those taking prescription medications or with existing health conditions.
Mechanism of Action
- Berberine's mechanism of action involves the activation of AMPK, which regulates glucose and lipid metabolism, and the modulation of various cellular pathways involved in these processes 2.
- The compound has also been shown to have anti-inflammatory and antioxidant effects, which may contribute to its potential health benefits 3.