What is the cause of a spontaneous scleral hematoma without a history of trauma?

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Last updated: April 18, 2025View editorial policy

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Differential Diagnosis for Scleral Hematoma without Trauma

  • Single most likely diagnosis
    • Hypertension: Scleral hemorrhage can occur due to uncontrolled high blood pressure, which causes blood vessels to rupture, leading to hematoma formation.
  • Other Likely diagnoses
    • Diabetes mellitus: Diabetic patients are prone to vascular complications, including retinal and scleral hemorrhages, due to microvascular damage.
    • Aging: As people age, the sclera becomes thinner and more susceptible to spontaneous hemorrhage.
    • Bleeding disorders (e.g., hemophilia, von Willebrand disease): Coagulopathy can increase the risk of spontaneous bleeding, including scleral hematoma.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Malignant hypertension: This is a severe form of hypertension that can cause rapid deterioration of vision and even death if left untreated.
    • Scleritis: Inflammation of the sclera can cause pain, redness, and swelling, and if left untreated, can lead to vision loss and other complications.
    • Orbital cellulitis or abscess: Infection of the orbit can spread to the sclera, causing hematoma and potentially life-threatening complications.
  • Rare diagnoses
    • Amyloidosis: This condition involves the deposition of abnormal proteins in various tissues, including the sclera, which can lead to spontaneous hemorrhage.
    • Scleral choristoma: A rare congenital condition where abnormal tissue grows in the sclera, potentially causing hemorrhage.
    • Sarcoidosis: An autoimmune disease that can affect various parts of the body, including the eyes, and cause scleral inflammation and hemorrhage.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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