What is the cause of a spontaneous scleral hematoma without trauma, accompanied by pain?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 18, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Scleral Hematoma without Trauma and Pain

  • Single most likely diagnosis
    • Subconjunctival hemorrhage: This condition is characterized by the accumulation of blood underneath the conjunctiva, often without any apparent trauma. It can cause a scleral hematoma appearance and is usually painless.
  • Other Likely diagnoses
    • Anticoagulant use: Patients on anticoagulant therapy may experience spontaneous bleeding, including scleral hematoma, due to their altered coagulation status.
    • Hypertension: Uncontrolled high blood pressure can lead to vascular rupture and subsequent bleeding, potentially causing a scleral hematoma.
    • Scleritis: Although typically painful, some forms of scleritis (e.g., posterior scleritis) may present with minimal pain and could be associated with a scleral hematoma.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Orbital tumor: A tumor in the orbit can cause erosion of blood vessels, leading to spontaneous bleeding, including a scleral hematoma.
    • Vascular malformation: Abnormal blood vessels, such as arteriovenous malformations, can rupture and cause bleeding, which may manifest as a scleral hematoma.
    • Inflammatory or infectious diseases (e.g., endophthalmitis, orbital cellulitis): These conditions can cause severe inflammation and potentially lead to vascular rupture and bleeding.
  • Rare diagnoses
    • Amyloidosis: This condition can cause vascular fragility and increase the risk of spontaneous bleeding, including scleral hematoma.
    • Scurvy: Vitamin C deficiency can lead to blood vessel fragility and increased risk of bleeding, potentially causing a scleral hematoma.
    • Ehlers-Danlos syndrome: This genetic disorder affects connective tissue and can increase the risk of vascular rupture and bleeding, including scleral hematoma.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.