From the Research
Effective Antibiotics Against P. mirabilis Respiratory Infections
- Cefepime has been shown to be effective against P. mirabilis, with no resistance observed in a study of 20 patients with pneumonia caused by this pathogen 1.
- Piperacillin-tazobactam, carbapenems, and cephalosporins have also been found to have high susceptibility levels against P. mirabilis 2.
- Imipenem and aztreonam have been reported to have low resistance rates among P. mirabilis strains 3.
Antibiotics with Limited Effectiveness
- Ampicillin has been shown to have high resistance rates among P. mirabilis strains, with 55% resistance observed in one study 1 and 100% resistance observed in another study 3 is not directly relevant to this point, but does show high resistance to ampicillin.
- Tetracycline has also been found to have high resistance rates, with 100% resistance observed in one study 1.
- Cephalothin, trimethoprim-sulfamethoxazole have been reported to have low susceptibilities against P. mirabilis 2.
Novel Therapeutic Targets
- Methionine tRNA synthetase (MetRS) has been identified as a potential target for novel antibiotics against P. mirabilis, with a homology model constructed and validated for this enzyme 4.
- Plant extracts, such as Pterocarpus angolensis leaf extracts, have been found to have antibacterial effects against P. mirabilis and may be a potential source of new antibiotics 5.