What is the next step in managing a 21-year-old male with a history of migraines, presenting with lower abdominal and back pain, and urinalysis (UA) findings of trace lysed blood and 1-2 red blood cells (RBCs)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: February 3, 2026View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Immediate Next Step: Non-Contrast CT Scan of Abdomen/Pelvis

This 21-year-old male requires urgent imaging with non-contrast CT scan of the abdomen and pelvis to evaluate for nephrolithiasis (kidney stones), which is the most likely diagnosis given his age, symptom pattern, and urinalysis findings. 1

Clinical Reasoning

Why Imaging is Essential

  • The urinalysis findings of trace lysed blood on macroscopic examination with only 1-2 RBCs on microscopy is consistent with urolithiasis - this pattern of minimal microscopic hematuria does not exclude significant urologic pathology 1

  • Lower abdominal and back pain in a young male with any hematuria (even trace) requires imaging to confirm or exclude urolithiasis, as this cannot be diagnosed with certainty on clinical grounds alone 1

  • Non-contrast CT is the gold standard imaging modality for suspected urolithiasis and should be obtained promptly in this clinical scenario 1

Why This Takes Priority Over Migraine Considerations

While the patient has a migraine history, several factors make this an inadequate explanation for his current presentation:

  • Abdominal migraine, though possible in adults, is a diagnosis of exclusion that requires ruling out all alternative diagnoses first 2, 3

  • The presence of hematuria (even trace amounts) is NOT a feature of abdominal migraine and mandates investigation for urologic pathology 2, 3

  • Lower back pain combined with abdominal pain and hematuria forms a classic triad for nephrolithiasis, which is far more common in this demographic than abdominal migraine 1

  • Abdominal migraine typically presents with periumbilical pain, not lower abdominal pain with back radiation, and would not explain the urinalysis findings 2, 3

Immediate Management Algorithm

Step 1: Obtain Imaging

  • Order non-contrast CT scan of abdomen and pelvis immediately to evaluate for urolithiasis 1

Step 2: Symptomatic Treatment While Awaiting Results

  • Administer ketorolac 30-60 mg IM for pain control - this NSAID is highly effective for renal colic and has minimal rebound headache risk 4
  • Provide antiemetic if nausea present (metoclopramide 10 mg IV or prochlorperazine 10 mg IV) 5

Step 3: Additional Laboratory Testing

  • Complete blood count and C-reactive protein to assess for infection or inflammation 1
  • Serum creatinine to evaluate renal function 1
  • Consider creatine phosphokinase (CPK) if rhabdomyolysis is a concern, though the urinalysis pattern (trace blood with minimal RBCs) is not classic for this diagnosis 6

Critical Pitfall to Avoid

Do not dismiss the hematuria as insignificant simply because microscopy shows only 1-2 RBCs. The combination of positive dipstick for blood with minimal microscopic RBCs can occur with:

  • Dilute urine causing RBC lysis 6
  • Small stones causing intermittent bleeding 1
  • Early presentation before significant hematuria develops 1

If Imaging is Negative

Only after urolithiasis and other structural causes are definitively excluded should abdominal migraine be considered:

  • Abdominal migraine diagnosis requires: recurrent episodes of periumbilical pain lasting 1-72 hours, normal physical examination between episodes, exclusion of all alternative diagnoses, and typically a strong family history of migraine 2, 3

  • Treatment for confirmed abdominal migraine would include: NSAIDs as first-line (ibuprofen 400-800 mg), with triptans as second-line if NSAIDs fail 7

  • Prophylactic therapy should be initiated if attacks occur ≥2 days per month despite acute treatment 7

References

Research

Acute Abdominal Pain in Adults: Evaluation and Diagnosis.

American family physician, 2023

Research

Abdominal migraine in the differential diagnosis of acute abdominal pain.

The American journal of emergency medicine, 2015

Research

Abdominal migraine, another cause of abdominal pain in adults.

The American journal of medicine, 2012

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Prochlorperazine for Acute Migraine Treatment

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Research

Urinalysis is an inadequate screen for rhabdomyolysis.

The American journal of emergency medicine, 2014

Guideline

Abdominal Migraine Treatment Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Related Questions

What to do for a 17-year-old female with abdominal pain after exercise?
What is the likely cause of sudden onset and resolution of lower abdominal pain in an 18-year-old?
What is the initial approach for an 18-year-old female with upper abdominal pain and normal vitals?
What is the recommended diagnostic workup for an 18-year-old female with intermittent sharp right upper quadrant (RUQ) abdominal pain?
What is the best course of action for a 15-year-old boy with severe abdominal pain, no nausea, no vomiting, no diarrhea, normal bowel and bladder habits, and present bowel sounds?
What are the considerations and dosing guidelines for using hyoscyamine (anticholinergic medication) in pediatric patients with gastrointestinal issues such as infantile colic or gastroesophageal reflux disease (GERD)?
What is the recommended treatment approach for a patient with microalbuminuria and a history of diabetes, hypertension, or cardiovascular disease?
What are the risks and management of nifedipine in a pregnant patient?
What could be the cause of a 64-year-old female's right-sided hip pain, radiating to the groin area, with a 1-week history, following antibiotic treatment for a tooth infection, and with a past medical history of renal cysts, high cholesterol, and high blood pressure?
What is the typical duration of lorazepam (Benzodiazepine) 1mg BID treatment for a patient with catatonia?
Is Symbicort (budesonide and formoterol) safe to use during pregnancy in patients with asthma or Chronic Obstructive Pulmonary Disease (COPD)?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.